期刊论文

Du, G.

中文

药物评价研究

1674-6376

2019

42

10

1935-1941

10.7501/j.issn.1674-6376.2019.10.004

河南省自然科学基金项目（182300410310）；

本校为其他机构

目的 观察杠板归对小鼠H22肝癌的抑制作用,分析其可能的作用机制.方法 建立H22皮下移植小鼠模型评价杠板归对肿瘤生长的影响;二甲苯诱导的耳肿胀评价杠板归对荷瘤小鼠炎症的影响;网络药理学分析杠板归抗肿瘤和抗炎可能的作用机制.结果 杠板归对H22皮下肿瘤生长有明显抑制作用(P＜0.05),显著降低二甲苯诱导的荷瘤小鼠耳肿胀(P＜0.05).通过上海有机所化学专业数据库以口服生物利用度(OB) ≥30％和类药性(DL) ≥0.18筛选杠板归4种有效成分,与生物芯片肝癌上下调基因蛋白分子对接得到106个预测靶点,预测靶点与TTD比对得到13个肝癌治疗靶点.蛋白相互作用网络(PPI)分析STAT3、IL-6、IL-1β、HBG2、TLR...

Objective To observe the inhibitory effect of Polygonum perfoliatum L. on H22 liver carcinoma in mice and explore its possible action mechanisms. Methods Effect of Polygonum perfoliatum L. on tumor growth was evaluated using H22 subcutaneously transplanted tumor model in mice, effect of Polygonum perfoliatum L on inflammation was examined by ear edema in tumor bearing mice. Network pharmacology was used to analyze the possible action mechanisms by which Polygonum perfoliatum L. exerts anti-tumor and anti-inflammation efficacy. Results Polygonum...