期刊论文

Zhu, K.

中文

药物评价研究

1674-6376

2019

42

7

1309-1313

10.7501/j.issn.1674-6376.2019.07.009

国家中医药管理重大项目（国中医药人教函[2012]228号）； 湖湘欧阳氏杂病流派辩证恶性肿瘤学术经验的研究（2017XJJJ21）；

本校为第一机构

目的 研究臭牡丹提取物对H22实体移植瘤的抑制作用及与B淋巴细胞瘤/白血病-2(Bcl-2)和Bcl-2相关X蛋白(Bax)表达的相关性.方法 皮下接种H22瘤株建立小鼠H22实体移植瘤模型.60只荷瘤鼠随机分为模型组、5-氟尿嘧啶(5-Fu)组和臭牡丹高、中、低剂量(2.18、1.09、0.55 g/kg)组,每组12只,各组分别给予生理盐水、5-Fu (25 mg/kg,1次/d)及不同浓度的臭牡丹提取物干预.连续给药14d后处死,检测小鼠体质量变化、抑瘤率及脾脏和胸腺指数;Western blot法检测Bcl-2和Bax蛋白的表达水平.结果 与模型组比较,臭牡丹高、中剂量组小鼠的肿瘤质量均显著降低(P＜0.01),胸腺和脾脏指数显著增加(P＜0.05);同时Bax蛋白的表...

Objective To study the inhibitory effect of Clerodendron bungei extract on H22 solid xenograft and its correlation with the expression of B cell lymphoma /leukemia-2 (Bcl-2) and Bcl-2 related X protein (Bax) proteins. Methods A mouse H22 solid xenograft model was established by subcutaneous inoculation of H22 tumor strain. Sixty tumor-bearing mice were randomly divided into model group, 5-fluorouracil (5-Fu) group and Clerodendron bungei high, medium and low dose groups, 12 rats in each group. Each group was given normal saline and 5-Fu (25 mg ...