Willed-movement training reduces motor deficits and induces a PICK1-dependent LTD in rats subjected to focal cerebral ischemia

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成果类型：

期刊论文

作者：

Tang, Qingping;Tan, Lihong;Yang, Xiaosu;Shen, Qin;Huang, Xiaosong;...

通讯作者：

Wu, Lixiang

作者机构：

[Li, Simin; Tang, Qingping; Wu, Lixiang] Cent S Univ, Sch Basic Med Sci, Dept Physiol, Changsha 410008, Hunan, Peoples R China.

[Tang, Qingping] Hunan Univ Chinese Med, Brain Hosp Hunan Prov, Dept Rehabil, Changsha 410007, Hunan, Peoples R China.

[Tan, Lihong; Huang, Xiaosong] Hunan Univ Chinese Med, Brain Hosp Hunan Prov, Dept Neurol, Changsha 410007, Hunan, Peoples R China.

[Shen, Qin; Nie, Jingjing; Yang, Xiaosu] Cent S Univ, Xiang Ya Hosp, Dept Neurol, Changsha 410008, Hunan, Peoples R China.

[Wang, Gaiqing] Shanxi Med Univ, Hosp 2, Dept Neurol, Taiyuan 030001, Shan Xi, Peoples R China.

通讯机构：

[Wu, Lixiang] C

Cent S Univ, Sch Basic Med Sci, Dept Physiol, Xiang Ya Rd 90, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

Long-term depression;Motor learning;PICK1;Stroke;Synaptic plasticity;Willed-movement training

期刊：

Behavioural Brain Research

ISSN：

0166-4328

年：

2013

卷：

256

期：

页码：

481-487

DOI：

10.1016/j.bbr.2013.08.039

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30973167]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2011M501301, 2012T50711]; Postdoctoral Science Foundation of Hunan ProvinceChina Postdoctoral Science Foundation; Postdoctoral Science Foundation of Central South University

机构署名：

本校为其他机构

院系归属：

针灸推拿与康复学院

摘要：

Willed-movement (WM) training has been implicated in the promotion of motor function in human stroke survivors and focal ischemic rats. However, the molecular basis of changes in synaptic transmission following WM training remains unclear. In addition, studies examining the influence of rehabilitative training, such as skilled motor learning, on long-term depression (LTD) of synapses in the primary motor cortex have produced conflicting results. To identify the possible effects of willed movement on motor recovery, on expression of the protein ...

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Willed-movement training reduces motor deficits and induces a PICK1-dependent LTD in rats subjected to focal cerebral ischemia

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