Molecular determinant for the tarantula toxin Jingzhaotoxin-I slowing the fast inactivation of voltage-gated sodium channels

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成果类型：

期刊论文

作者：

Tao, Huai*（陶怀）;Chen, Xia;Lu, Min;Wu, Yuanyuan;Deng, Meichun;...

通讯作者：

Liang, Songping;Tao, Huai（陶怀）

作者机构：

[Tao, Huai] Hunan Univ Chinese Med, Dept Biochem & Mol Biol, Changsha 410208, Hunan, Peoples R China.

[Zeng, Xiongzhi; Wu, Yuanyuan; Liu, Zhonghua; Lu, Min; Liang, Songping] Hunan Normal Univ, Coll Life Sci, Key Lab Prot Chem & Dev Biol, Minist Educ, Changsha 410081, Hunan, Peoples R China.

[Chen, Xia] Cent S Univ, Second Xiangya Hosp, Dept Orthoped, Changsha 410011, Hunan, Peoples R China.

[Tao, Huai] Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, Changsha 410208, Hunan, Peoples R China.

[Deng, Meichun] Cent S Univ, State Key Lab Med Genet, Changsha 410013, Hunan, Peoples R China.

通讯机构：

[Tao, Huai; Liang, Songping] H

Hunan Normal Univ, Coll Life Sci, Key Lab Prot Chem & Dev Biol, Minist Educ, Changsha 410081, Hunan, Peoples R China.

Hunan Univ Chinese Med, Dept Biochem & Mol Biol, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Inactivation;Jingzhaotoxin-I;Mutation;Voltage-gated sodium channels

期刊：

Toxicon

ISSN：

0041-0101

年：

2016

卷：

111

期：

页码：

13-21

DOI：

10.1016/j.toxicon.2015.12.009

基金类别：

National 973 Project of ChinaNational Basic Research Program of China [2010CB529801]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81503276, 31100764]; Scientific Research Fund of Hunan Provincial Education DepartmentHunan Provincial Education Department [15C1044]; Research Foundation of Stem Cell Regulation and Application of Hunan University of Chinese Medicine [2013GXB01]; Scientific Research Starting Foundation of Hunan University of Chinese Medicine [9982-1001-010]; Cooperative Innovation Center of Engineering and New Products for Developmental Biology of Hunan Province [20134486]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2012M521536]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

中医学院

药学院

摘要：

Peptide toxins often have divergent pharmacological functions and are powerful tools for a deep review on the current understanding of the structure-function relationships of voltage-gated sodium channels (VGSCs). However, knowing about the interaction of site 3 toxins from tarantula venoms with VGSCs is not sufficient. In the present study, using whole-cell patch clamp technique, we determined the effects of Jingzhaotoxin-I (JZTX-I) on five VGSC subtypes expressed in HEK293 cells. The results showed that JZTX-I could inhibit the inactivation of rNav1.2, rNav1.3, rNav1.4, hNav1.5 and hNav1.7 c...

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Molecular determinant for the tarantula toxin Jingzhaotoxin-I slowing the fast inactivation of voltage-gated sodium channels

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