Molecular determinant for the tarantula toxin Jingzhaotoxin-I slowing the fast inactivation of voltage-gated sodium channels

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Tao, Huai（陶怀）;Chen, Xia;Lu, Min;Wu, Yuanyuan;Deng, Meichun;...

通讯作者：

Liang, SP;Tao, H

作者机构：

[Tao, Huai] Hunan Univ Chinese Med, Dept Biochem & Mol Biol, Changsha 410208, Hunan, Peoples R China.

[Zeng, Xiongzhi; Wu, Yuanyuan; Liu, Zhonghua; Lu, Min; Liang, Songping] Hunan Normal Univ, Coll Life Sci, Key Lab Prot Chem & Dev Biol, Minist Educ, Changsha 410081, Hunan, Peoples R China.

[Chen, Xia] Cent S Univ, Second Xiangya Hosp, Dept Orthoped, Changsha 410011, Hunan, Peoples R China.

Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, Changsha 410208, Hunan, Peoples R China.

[Deng, Meichun] Cent S Univ, State Key Lab Med Genet, Changsha 410013, Hunan, Peoples R China.

通讯机构：

[Tao, H ; Liang, SP ] H

Hunan Normal Univ, Coll Life Sci, Key Lab Prot Chem & Dev Biol, Minist Educ, Changsha 410081, Hunan, Peoples R China.

Hunan Univ Chinese Med, Dept Biochem & Mol Biol, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Inactivation;Jingzhaotoxin-I;Mutation;Voltage-gated sodium channels

期刊：

Toxicon

ISSN：

0041-0101

年：

2016

卷：

111

期：

页码：

13-21

DOI：

10.1016/j.toxicon.2015.12.009

基金类别：

National 973 Project of China#&#&#2010CB529801 National Natural Science Foundation of China#&#&#81503276#&#&#31100764 Scientific Research Fund of Hunan Provincial Education Department#&#&#15C1044 Research Foundation of Stem Cell Regulation and Application of Hunan University of Chinese Medicine#&#&#2013GXB01 the Scientific Research Starting Foundation of Hunan University of Chinese Medicine#&#&#9982-1001-010 the Cooperative Innovation Center of Engineering and New Products for Developmental Biology of Hunan Province#&#&#20134486 China Postdoctoral Science Foundation#&#&#2012M521536

机构署名：

本校为第一且通讯机构

院系归属：

医学院

中医学院

药学院

摘要：

Peptide toxins often have divergent pharmacological functions and are powerful tools for a deep review on the current understanding of the structure-function relationships of voltage-gated sodium channels (VGSCs). However, knowing about the interaction of site 3 toxins from tarantula venoms with VGSCs is not sufficient. In the present study, using whole-cell patch clamp technique, we determined the effects of Jingzhaotoxin-I (JZTX-I) on five VGSC subtypes expressed in HEK293 cells. The results showed that JZTX-I could inhibit the inactivation of rNav1.2, rNav1.3, rNav1.4, hNav1.5 and hNav1.7 c...

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Molecular determinant for the tarantula toxin Jingzhaotoxin-I slowing the fast inactivation of voltage-gated sodium channels

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