期刊论文

Protein Structural Characteristics and Antigen Epitopes Analysis of TMPRSS2 Correlated with SARS-CoV-2

中文

微生物学杂志

1005-7021

2021

41

01

58-68

10.3969/j.issn.1005-7021.2021.01.008

2019年湖南省教育厅科学研究项目优秀青年项目（19B436）； 2019年度湖南省大学生创新创业训练计划项目（S202010541032）；

本校为第一机构

采用生物信息学方法分析预测新型冠状病毒（Severe acute respiratory syndrome coronavirus 2, SARS-CoV-2）跨膜蛋白酶丝氨酸2（transmembrane protease serine 2, TMPRSS2）的理化特性、结构特征和抗原表位,为抗SARS-CoV-2药物研发提供参考。利用ProtParam、ProtScale分析预测TMPRSS2蛋白酶的理化特性;利用COILS Server、SignalP、TMPred、TargetP Server、NetPhos Server、NetNGlyc Server服务器对TMPRSS2蛋白酶结构进行功能结构的分析预测;利用SOPMA、Pfam、SWISS-MODEL分析预测TMPRSS2蛋白酶高级结构;利用IEBD分析预测TMPRSS2蛋白酶B细胞、T细胞表位。TMPRSS2蛋白酶氨基酸组成数为492个,其...

This study adopted bioinformatics methods to analyzes and prognoses the physicochemical properties, structural characteristics,and antigen epitopes of transmembrane protease serine 2 (TMPRSS2),to provide references for medicine research and development against SARS-CoV-2. The physicochemical properties of TMPRSS2 were analyzed and predicted adopting ProtParam and ProtScale; the structural and functional structures of TMPRSS2 protease were analyzed and predicted using servers of COILS Server,SignalP,TMPred,TargetP Server, NetPhos Server,Net-NGlyc Server; the high-level structure of TMPRSS2 prot...