Numb downregulation suppresses cell growth and is associated with a poor prognosis of human hepatocellular carcinoma

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Xie, Chengzhi;Lu, Zhenhui;Liu, Guoxing;Fang, Yu;Liu, Jiefeng;...

通讯作者：

Xu, Xundi

作者机构：

[Li, Xiaocheng; Qian, Ke; Hu, Jixiong; Liu, Guoxing; Fang, Yu; Zhong, Dewu; Lei, Xiaohua; Huang, Zhao; Liu, Jiefeng; Xu, Xundi; Zhang, Yueming; Wu, Xiaolong; Wang, Fusheng; Hu, Zecheng; Xie, Chengzhi; Huang, Shengfu] Cent S Univ, Dept Surg, Xiangya Hosp 2, Div Hepatobiliary Pancreat Surg, Changsha 410011, Hunan, Peoples R China.

[Xie, Chengzhi] Hunan Univ Chinese Med, Affiliated Hosp 2, Dept Gen Surg, Changsha 410005, Hunan, Peoples R China.

[Lu, Zhenhui] Ningxia Med Univ, Gen Hosp, Dept Hepatobiliary Surg, Yinchuan 750004, Ningxia Hui Aut, Peoples R China.

[Xu, Xundi] Cent S Univ, Dept Surg, Xiangya Hosp 2, Div Hepatobiliary Pancreat Surg, 139 Renmin Zhong Rd, Changsha 410011, Hunan, Peoples R China.

通讯机构：

[Xu, Xundi] C

Cent S Univ, Dept Surg, Xiangya Hosp 2, Div Hepatobiliary Pancreat Surg, 139 Renmin Zhong Rd, Changsha 410011, Hunan, Peoples R China.

语种：

英文

关键词：

Apoptosis;Hepatocellular carcinoma;Numb;Prognosis;Proliferation

期刊：

International Journal of Molecular Medicine

ISSN：

1107-3756

年：

2015

卷：

期：

页码：

653-660

DOI：

10.3892/ijmm.2015.2279

机构署名：

本校为其他机构

院系归属：

第二中医临床医学院

摘要：

Numb, an endocytic adaptor, is a known cell fate determinant that participates in asymmetric cell division. The present study aimed to explore the potential roles of Numb in hepatocarcinogenesis. Numb expression was investigated in hepatocellular carcinomas (HCC) with reverse transcription-quantitative polymerase chain reaction and immunohistochemical examination; its association with the prognosis of HCC patients was analyzed. In addition, the effects of Numb deletion on proliferation of HCC cells and its relevant molecules were evaluated in Huh7 and HepG2 cells. Numb overexpression was obser...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Numb downregulation suppresses cell growth and is associated with a poor prognosis of human hepatocellular carcinoma

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问