Gut-brain axis mediated by intestinal content microbiota was associated with Zhishi Daozhi decoction on constipation

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成果类型：

期刊论文

作者：

Fang, Leyao;Yi, Xin;Shen, Junxi;Deng, Na*;Peng, Xinxin

通讯作者：

Peng, XX;Deng, Na;Deng, N

作者机构：

[Peng, Xinxin; Peng, XX; Fang, Leyao] Hunan Univ Chinese Med, Hosp 1, Changsha, Peoples R China.

[Shen, Junxi; Peng, Xinxin; Yi, Xin; Deng, Na; Peng, XX; Deng, N; Fang, Leyao] Hunan Univ Chinese Med, Domest Class Discipline Construction Project Chine, Changsha, Peoples R China.

[Shen, Junxi; Yi, Xin; Deng, N; Deng, Na; Fang, Leyao] Hunan Univ Chinese Med, Sch Tradit Chinese Med, Changsha, Peoples R China.

通讯机构：

[Deng, N ; Peng, XX ; Deng, N] H

Hunan Univ Chinese Med, Hosp 1, Changsha, Peoples R China.

Hunan Univ Chinese Med, Domest Class Discipline Construction Project Chine, Changsha, Peoples R China.

Hunan Univ Chinese Med, Sch Tradit Chinese Med, Changsha, Peoples R China.

语种：

英文

关键词：

Zhishi Daozhi decoction;brain-gut axis;constipation;high-fat and high-protein diet;intestinal content microbiota;microbial diversity

期刊：

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

ISSN：

2235-2988

年：

2025

卷：

页码：

1539277

DOI：

10.3389/fcimb.2025.1539277

基金类别：

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported the Natural Science Foundation of Hunan Province (No. 2022JJ40332) and the Domestic First-class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine (4901-020000200207).

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

摘要：

BACKGROUND: Constipation is a common digestive system disorder, which is closely related to the intestinal flora. Zhishi Daozhi decoction (ZDD) is a traditional Chinese medicine prescription used to treat constipation caused by indigestion. This study is to evaluate the efficacy of ZDD in treating constipation and to elucidate the underlying mechanism. METHODS: In this study, Kunming mice were administered a high-protein diet (HFHPD) and loperamide hydrochloride injections to induce constipation. The mice then received varying doses (2.4, 4.7, and 9.4 mg/kg) of ZDD for seven days. Following th...

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Gut-brain axis mediated by intestinal content microbiota was associated with Zhishi Daozhi decoction on constipation

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