SOCS1, the feedback regulator of STAT1/3, inhibits the osteogenic differentiation of rat bone marrow mesenchymal stem cells

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhang, Ying;Jing, Zhenhao;Cao, Xiangyang;Wei, Qiushi;He, Wei;...

通讯作者：

Li, WY;Wang, HB

作者机构：

[Zhang, Leilei; Li, Peifeng; Li, Jitian; Cao, Xiangyang; Li, WY; Liu, Youwen; Li, Wuyin; Zhang, Ying] Luoyang Orthoped Traumatol Hosp, Orthoped Hosp Henan Prov, Med Ctr Hip, Luoyang 471002, Henan, Peoples R China.

[Zhuang, Zhikun; Wang, Haibin; Zhang, Ying] Guangzhou Univ Chinese Med, Guangzhou 510405, Guangdong, Peoples R China.

[Jing, Zhenhao; Yuan, Qiang; Dong, Yipping] Henan Univ Chinese Med, Zhengzhou 450046, Henan, Peoples R China.

[Hong, Zhinan; Wei, Qiushi; He, Wei] Guangzhou Univ Chinese Med, Inst Orthopaed, Guangzhou 510240, Guangdong, Peoples R China.

[Hong, Zhinan; Wei, Qiushi; He, Wei] Guangzhou Univ Chinese Med, Affiliated Hosp 3, Guangzhou 510240, Guangdong, Peoples R China.

通讯机构：

[Li, WY ] L

[Wang, HB ] G

Luoyang Orthoped Traumatol Hosp, Orthoped Hosp Henan Prov, Med Ctr Hip, Luoyang 471002, Henan, Peoples R China.

Guangzhou Univ Chinese Med, Guangzhou 510405, Guangdong, Peoples R China.

语种：

英文

关键词：

BMSC;OD;SOCS1;STAT1/3

期刊：

Gene

ISSN：

0378-1119

年：

2022

卷：

821

页码：

146190

DOI：

10.1016/j.gene.2022.146190

机构署名：

本校为其他机构

摘要：

Our study showed that Signal transducer and activator of transcription (STAT)1 and STAT3 phosphorylation was firstly upregulated in the early stage of osteogenic differentiation (OD), and quickly eliminated in hours. Following with phosphorylation of STAT1/3, its downstream feedback regulator Suppressor of cytokine signaling 1 (SOCS1) protein also underwent a quick elevation. Further activation and deactivation of STAT1/3, by administrated with Colivelin and Nifuroxazide in Bone mesenchymal stem cells (BMSCs), increased and decreased SOCS1 expression, inhibited and promoted OD of BMSCs, respec...

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SOCS1, the feedback regulator of STAT1/3, inhibits the osteogenic differentiation of rat bone marrow mesenchymal stem cells

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