Design, Synthesis and Biological Evaluation of Benzopyran Derivatives as KATP Channel Openers

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhou, Jinpei;Qian, Hai;Zhang, Huibin*;Gao, Hui;Huang, Wenlong;...

通讯作者：

Zhang, Huibin

作者机构：

[Zhou, Jinpei] China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Peoples R China.

[Gao, Hui; Qian, Hai; Zhu, Xiaoyun; Ni, Shuaijian; Zhang, Huibin; Huang, Wenlong] China Pharmaceut Univ, Ctr Drug Discovery, Nanjing 210009, Peoples R China.

[Zhang, Chuntao] Hunan Univ Tradit Chinese Med, Organ & Med Chem Teaching & Res Sect, Changsha 410208A, Peoples R China.

[Zhang, Huibin] China Pharmaceut Univ, Ctr Drug Discovery, 24 Tongjiaxiang, Nanjing 210009, Peoples R China.

通讯机构：

[Zhang, Huibin] C

China Pharmaceut Univ, Ctr Drug Discovery, 24 Tongjiaxiang, Nanjing 210009, Peoples R China.

语种：

英文

关键词：

Anti-hypertension;KATP Channel Openers;Benzopyran derivatives;Synthesis

期刊：

LETTERS IN DRUG DESIGN & DISCOVERY

ISSN：

1570-1808

年：

2010

卷：

期：

页码：

415-420

DOI：

10.2174/157018010791306560

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30973638]

机构署名：

本校为其他机构

摘要：

In order to complete the SAR and discover new potent and selective PCOs, some changes were made to the C-4 and C-2 substitutions of cromakalim. A series of 4 -amino acid substituted -2, 2-dialkylchromans structurally related to cromakalim were synthesized and evaluated, as ATP-sensitive potassium channel openers (8a-l). Preliminary biological tests suggested that these compounds exhibited potent to mild relaxation activity of the KCl-contracted rat aortic strips. Compounds 8b (IC50 =0.25μM), 8f (IC50 =6.44μM) and 8j (IC50 =8.65μM) exhibited ...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Design, Synthesis and Biological Evaluation of Benzopyran Derivatives as KATP Channel Openers

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问