期刊论文

中文

光明中医

1003-8914

2003

4

33-35

10.3969/j.issn.1003-8914.2003.04.031

湖南省自然科学基金

本校为第一机构

观察牛角地黄冲剂对大鼠免疫性血小板减少模型血栓素A2(TXA2)、前列环素I2(PGI2)的影响.将100只SD大鼠随机分成正常对照组、模型对照组、强的松对照组、牛角地黄冲剂高剂量组、牛角地黄冲剂低剂量组.除正常组外,各组均以注射免抗大鼠血小板血清(APS)造模,分别灌药和蒸馏水,每日1次,连续11天,分别在第7天和第11天各测一半大鼠血浆血栓素B2(TXB2)、6-酮-前列腺素F1α(6-keto-PGF1α)值,并作骨髓涂片检查.结果显示强的松组6-keto-PGF1α水平明显高于正常组水平(P＜0.05)而牛角地黄冲剂高剂量组6-keto-PGF1α浓度明显高于模型组,且接近正常组水平.而各组TXB2水平改变均不显著.说明牛黄地黄冲剂有改善...

Objective:To observe the effects of thromboxame A\-2(TXA\-2),proctacyclin I\-2(PGI\-2) on rat Immunologic thrombocytopenic purpura(ITP) model by infusion Niujiao Dihuang.Methods:100 SD rats were distributed to normal group,model group,prednisone group,infusion Niujiao Dihuang higher dose group,infusion Niujiao Dihuang lower dose group in random.Except normal group,all rats were injected anti\|rat platelet serum(APS) to creats ITP model,Half of rats was detected thromboxane B\-2(TXB\-2)and 6\|keto\|prostocyclin F1 α(6\|keto\|PGF1α)after giving...