Inhibition of transient receptor potential canonical 6 attenuates fibroblast-like synoviocytes mediated synovial inflammation and joint destruction in rheumatoid arthritis

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Liu, G.;Xu, D.;He, Y.;Xu, J.;Huang, S.;...

通讯作者：

Huang, J;Li, J

作者机构：

[He, Y.; Liu, G.; Huang, J.] Guangzhou Med Univ, Affiliated Hosp 5, Dept Orthopaed, Guangzhou 511436, Peoples R China.

[Liu, G.] Guangzhou Med Univ, Dept Orthopaed, Qingyuan Peoples Hosp, Affiliated Hosp 6, Qingyuan, Peoples R China.

[Xu, D.; Qiu, X.; Huang, J.] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Orthopaed, Guangzhou, Peoples R China.

[Xu, J.; Zhang, W.; Huang, J.] Zengcheng Dist Peoples Hosp, Dept Orthopaed, Guangzhou, Peoples R China.

[Huang, S.] Sun Yat Sen Univ, Affiliated Hosp 7, Dept Orthopaed, Shenzhen, Peoples R China.

通讯机构：

[Li, J ; Huang, J ] G

Guangzhou Med Univ, Affiliated Hosp 5, Dept Orthopaed, Guangzhou 511436, Peoples R China.

Guangzhou Med Univ, Sch Basic Med Sci, Guangzhou 511436, Peoples R China.

语种：

英文

关键词：

Fibroblast-like synoviocytes;Rheumatoid arthritis;Transient receptor potential canonical 6

期刊：

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY

ISSN：

0392-856X

年：

2021

卷：

期：

页码：

115-124

DOI：

10.55563/clinexprheumatol/rffvyg

基金类别：

Funding: this work was supported by grants from the National Natural Science Foundation of China (grant no. 81470205), the Natural Science Foundation of Guangdong (grant no. 2017A030313606), and the Science and Technology Project of Guangzhou (grant no. 201707010081). Competing interests: none declared.

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摘要：

Objective We aimed to define the importance of transient receptor potential canonical 6 (TRPC6) expression and function in fibroblast-like synoviocytes (FLSs) and to investigate the contribution of TRPC6 in the model of rheumatoid arthritis (RA). Methods We compared TRPC6 expression levels in FLSs from RA patients (RA-FLSs), and in FLSs from osteoarthritis (OA) patients (OA-FLSs). By using vitro functional assays which united with small interfering RNA-induced knockdown and functional modulation of TRPC6 in RA-FLSs. Finally, we confirmed the ef...

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Inhibition of transient receptor potential canonical 6 attenuates fibroblast-like synoviocytes mediated synovial inflammation and joint destruction in rheumatoid arthritis

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