The invention belongs to the field of targeted drug research and specifically relates to a glycyrrhetinic acid and/or folic acid ligand modified cantharidin solid lipid nanoparticle and a preparationmethod thereof. The product comprises a carrier and a ligand connected to the carrier, wherein the carrier is cantharidin solid lipid nanoparticles, and the ligand is 3-succinic acid-30-stearyl glycyrrhetinate and/or folate-polyethylene glycol-cephalin. The product is high in entrapment efficiency, large in drug lo...