期刊论文

Effects of Compound Baihe Shugan Anshen on the expression of cytokines and monoamine neurotransmitters in anxious depression rats model

中文

中国临床药理学杂志

1001-6821

2017

33

21

2162-2166

10.13699/j.cnki.1001-6821.2017.21.020

国家自然科学基金资助项目（81403387） 湖南省科技厅重点基金资助项目（2015DK3003）

本校为第一机构

目的研究百合疏肝安神汤对焦虑性抑郁症模型大鼠细胞因子及单胺类神经递质表达的影响。方法SD大鼠按体重被随机分为7组:模型组、阳性药对照组(文拉法辛6.75 mg·kg ~(- 1))、高中低3个剂量实验组(百合疏肝安神汤, 24.28, 12.24, 6.12 g·kg ~(- 1)),空白对照组(正常饲养)和溶媒组(皮下注射0.9 %NaCl+5%二甲基亚砜)。经连续21 d慢性束缚应激+孤笼饲养,并皮下注射皮质酮(30 mg·kg ~(- 1))来复制焦虑性抑郁症动物模型。造模同时,灌胃给药。用酶联免疫吸附法检测血浆、前额叶皮层(PFC)、海马和杏仁核组织中肿瘤坏死因子- α(TNF - α)含量;以免疫印迹法检测PFC、海马和杏仁核组织中吲哚胺2,3 -双加...

Objective To investigate the effects of Compound Baihe Shugan Anshen(CBSA) on the expression of cytokines and monoamine neurotransmitters in anxious depression model rats. Methods According to weight,SD rats were randomly divided into 7 groups: model group, positive control group(venlafaxine,6.75 mg·kg ~(- 1)), experimental - H, M,L groups (CBSA,24.28,12.24,6.12 g·kg ~(- 1)). Chronic restraint stress + solitary feeding for 21 days, and subcutaneous injection corticosterone 30 mg·kg ~(- 1) were used to replicate the anxiety depression animal ...