期刊论文

Progress in effects of WNT5A/Ror2 signaling pathway on cancer metastasis

中文

中国临床药理学杂志

1001-6821

2017

33

1

84-86

10.13699/j.cnki.1001-6821.2017.01.023

国家自然科学基金资助项目（81000946,81270359,81173047,31371161） 湖南省教育厅重点基金资助项目（15A138） 中药学湖南省重点学科科技基金资助项目（ZY201502）

本校为第一机构

Wnt5a是一种富含半胱氨酸结构域的分泌性糖蛋白,在生物体内Wnts家族参与调控细胞命运、胚胎发育、细胞增殖、迁移和分化等重要过程。Wnt5a参与了平面细胞极性、Wnt - Ca~(2+)及Wnt /JNK等非经典Wnt信号通路的激活。 Ror2作为受体酪氨酸激酶家族中的成员之一,能够作为Wnt5a的受体或共受体参与调控Wnt5a诱导的非经典Wnt通路。Wnt5a /Ror2在肿瘤细胞和具有侵袭性的肿瘤细胞中具有持续激活的能力,通过调节MMP - 13的表达导致丝状伪足的形成,最终增强细胞的侵袭力。本文将对Wnt5a /Ror2介导的信号通路对肿瘤转移方面的影响做一综述。

Wnt5a belongs to the large WNT family of cysteine - rich secreted glycoproteins,which is involved in multiple signaling pathways that regulates a variety of cellular processes including cell fate,embryonic development,cell motility,proliferation and differentiation. Growing evidences have shown that Wnt5a was involved in the activation of noncanonical Wnt signaling, including planar cell polarity (PCP), Wnt - Ca~(2+),and Wnt /JNK pathways. As a member of Ror - family of receptor tyrosine kinases,Ror2,acts as a receptor or coreceptor for Wnt5a and mediates noncanonial Wnt5a signaling. Wnt5a /Ro...