期刊论文

Effects and mechanism of Wenyangzhenshuai Granules on the rabbits with chronic heart failure induced by adriamycin

中文

中国临床药理学杂志

1001-6821

2020

36

9

1085-1087

10.13699/j.cnki.1001-6821.2020.09.011

国家自然科学基金资助项目(81173213,81704-061) 湖南省教育厅科学研究基金资助项目(18C0405) 湖南省大学生创新创业训练计划基金资助项目(2019-1696) 湖南省高校科技创新团队中西医结合防治心脑疾病的相关基础研究基金资助项目(2015CXTD) 湖南创新型省份建设专项科普专项基金资助项目(2019ZK4012) 湖南中医药大学校级科研基金资助项目(2018XJJJ23)。

本校为第一机构

目的观察温阳振衰颗粒对阿霉素诱导性慢性心力衰竭（CHF）模型兔的心肌Toll样受体2（TLR2）和核转录因子-κB（NF-κB）蛋白表达的影响。方法耳缘静脉注射阿霉素构建CHF兔模型。按心功能分层将造模成功兔随机分为5组:模型组、对照组和低、中、高3个剂量实验组,每组11只。另取11只正常兔作为正常组。在第5周开始,低、中、高3个剂量实验组分别予温阳振衰颗粒0. 4,0. 8,1. 6 g·kg-1用蒸馏水稀释后灌胃;对照组予以依那普利5 mg·kg-1配以蒸馏水灌胃,正常组和模型组均灌服等量蒸馏水,每日1次,均连续灌胃4周。用蛋白质印迹法检测心肌TLR2和NF-κB蛋白的表达。结果正常组、模型组、对照组和低、中、高...

Objective To observe the effects of Wenyangzhenshuai Granules on the expression of Toll - like receptor 2( TLR2) and nuclear factor kappa B( NF - κB) of the myocardial tissue in the rabbits with chronic heart failure( CHF) induced by adriamycin. Methods The CHF model was established by intravenous injection of adriamycin at ear margin. The CHF model rabbits were randomly divided into five groups: model group,control group and experimental - L,experimental - M and experimental - H groups,each group had 11 rabbits. The other 11 rabbits were not ...