Taohong Siwu Decoction enhances human bone marrow mesenchymal stem cells proliferation, migration and osteogenic differentiation via VEGF-FAK signaling in vitro

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成果类型：

期刊论文

作者：

Lu, Xiaolong;Li, Juan;Zhou, Biao;Lu, Xuedi;Li, Wei;...

通讯作者：

Xiaolong Lu

作者机构：

[Lu, Xiaolong] Hunan Univ Chinese Med, Affiliated Hosp 1, Dept Orthoped, Changsha 410005, Hunan, Peoples R China.

[Lu, Xuedi; Li, Wei; Li, Juan; Ouyang, Jian] Hunan Univ Chinese Med, Affiliated Hosp 2, Dept Orthoped, Changsha 410005, Hunan, Peoples R China.

[Zhou, Biao] Chinese Acad Chinese Med Sci, Wangjing Hosp, Dept Orthoped, Beijing 100102, Peoples R China.

[Zhou, Biao] Univ South China, Xiangtan Hosp, Dept Orthoped, Xiangtan 411101, Hunan, Peoples R China.

[Lu, Xiaolong] 233 Cai E Bei Rd, Changsha 410005, Hunan, Peoples R China.

通讯机构：

[Xiaolong Lu] D

Department of Orthopedics, Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, 410005, Hunan Province, PR China

语种：

英文

关键词：

Bone marrow mesenchymal stem cells (BMSCs);Focal adhesion kinase (FAK)-Src;Migration;Taohong Siwu Decoction (THSWD);Vascular endothelial growth factor (VEGF);Viability

期刊：

Journal of Ethnopharmacology

ISSN：

0378-8741

年：

2023

卷：

307

页码：

116203

DOI：

10.1016/j.jep.2023.116203

基金类别：

scientific research project of Hunan Provincial Department of Education [19b420]; Scientific Research Project of Hunan Health and Family Planning Commission, China [202104072068]; University level scientific research fund project of Hunan University of Chinese Medicine [2020XJJJ053]; Project of Hunan Administration of Traditional Chinese Medicine, China [2021030]

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

第二中医临床医学院

摘要：

ETHNOPHARMACOLOGICAL RELEVANCE: Taohong Siwu Decoction (THSWD) is a conventional traditional Chinese prescription aiming at promoting blood circulation and alleviating blood stasis. It is widely prescribed in instances of ischemic strokes, cardiovascular diseases, osteoporosis and bone fracture. However, its molecular functions in bone formation remain uncharacterized. AIM OF STUDY: This study aims to explore the potential effects of THSWD treatment on human bone marrow mesenchymal stem cells (BMSCs) proliferation, osteogenic differentiation, a...

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Taohong Siwu Decoction enhances human bone marrow mesenchymal stem cells proliferation, migration and osteogenic differentiation via VEGF-FAK signaling in vitro

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