期刊论文

microRNA -720 Expression level and Its Relationship with Clinical Pathological Features in Breast Cancer

中文

中国保健营养

1004-7484

2015

7

2-3,5

81302328:国家自然科学基金 2013FJ4059:湖南省科技厅科技项目

本校为第一机构

目的：：探讨 miR－720在乳腺癌中的表达水平与临床病理特征的关系.方法：应用 QuanG titative stem－loop RT – PCR 检测110例乳腺癌组织中 miR－720的表达水平,分析其与乳腺癌患者临床病理特征的关系.结果：miR－720表达水平与乳腺癌患者首诊时淋巴结是否转移有关(P ＝0．001).在首诊有淋巴结转移的病例中,miR－720高表达组5年生存率高于 miR－720低表达组(P ＝0．038).结论：miR－720在乳腺癌组织的表达水平与患者的淋巴结转移及预后密切相关,可能成为乳腺癌诊断及预后判断的新的分子标志.

Objective:To investigate the expression level of miR-720 in breast cancer and its relationship with clinicopathological features of breast cancer(BC).Methods:The method of quantitaG tive stem- loop RT – PCR was used to detect the expression levels of miR - 720 in 1 10 cases of breast cancer tissue and analyze its relationship with clinical pathological characteristics of BC patients. Results:The expression of miR-720 is associated with lymph node metastasis states when initially diG agnosed(P =0.001).When initially diagnosed with lymph node me...