Pharmacological inhibition of TRPV4 channel suppresses malignant biological behavior of hepatocellular carcinoma via modulation of ERK signaling pathway

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成果类型：

期刊论文

作者：

Fang, Yu;Liu, Guoxing;Xie, Chengzhi;Qian, Ke;Lei, Xiaohua;...

通讯作者：

Xu, Xundi

作者机构：

[Liu, Gao; Qian, Ke; Hu, Jixiong; Liu, Guoxing; Fang, Yu; Du, Huihui; Lei, Xiaohua; Liu, Qiang; Cao, Zhenyu; Xu, Xundi; Liu, Sushun; Fu, Jie; Huang, Shengfu] Cent S Univ, Xiangya Hosp 2, Hunan Prov Key Lab Hepatobiliary Dis Res, Dept Surg,Div Hepatobiliary & Pancreat Surg, Changsha 410011, Hunan, Peoples R China.

[Xie, Chengzhi] Hunan Univ Chinese Med, Affiliated Hosp 2, Dept Gen Surg, Changsha 410005, Hunan, Peoples R China.

通讯机构：

[Xu, Xundi] C

Cent S Univ, Xiangya Hosp 2, Hunan Prov Key Lab Hepatobiliary Dis Res, Dept Surg,Div Hepatobiliary & Pancreat Surg, Changsha 410011, Hunan, Peoples R China.

语种：

英文

关键词：

TRPV4;Hepatocellular carcinoma;Apoptosis;Migration;ERK;EMT

期刊：

Biomedicine & Pharmacotherapy

ISSN：

0753-3322

年：

2018

卷：

101

页码：

910-919

DOI：

10.1016/j.biopha.2018.03.014

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81171933, 81272475]

机构署名：

本校为其他机构

院系归属：

第二中医临床医学院

摘要：

TRPV4 (transient receptor potential vanilloid 4), a member of the TRP superfamily, has been reported to correlate with several different forms of cancers. However, the role of TRPV4 in human hepatocellular carcinoma (HCC) remains unclear. The present study demonstrated that elevated expression of TRPV4 was shown in HCC tumor tissues when compared with paired non-tumoral livers both in protein and mRNA levels. Furthermore, the enhanced expression of TRPV4 was highly associated with histological grade (P = 0.036) and the number of tumors (P = 0.0...

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Pharmacological inhibition of TRPV4 channel suppresses malignant biological behavior of hepatocellular carcinoma via modulation of ERK signaling pathway

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