期刊论文

Lu, Fangguo

英文

Biomedicine & Pharmacotherapy

0753-3322

2020

132

110902

10.1016/j.biopha.2020.110902

We would like to thank National Natural Science Foundation ( 81803964 , 81774126 , 82074250 ), China Postdoctoral Science Foundation ( 2018M630906 , 2019T120707 ), Natural Science Foundation of Hunan Province ( 2020JJ4465 , 2020JJ4063 ), Training Program for Outstanding Young Innovators of Changsha, Key Subjects of Hunan University of Chinese Medicine 《pathogenic biology》(NO. 1) and First-class Discipline Construction Project of Basic Medicine in 13th Five-Year Plan of Hunan University of Chinese Medicine (No. 6) for the financial support. We would like to thank Editage ( www.editage.cn ) for English language editing.

本校为第一且通讯机构

Aptamers are single-stranded nucleic acid sequences that can bind to target molecules with high selectivity and affinity. Most aptamers are screened in vitro by a combinatorial biology technique called systematic evolution of ligands by exponential enrichment (SELEX). Since aptamers were discovered in the 1990s, they have attracted considerable attention and have been widely used in many fields owing to their unique advantages. In this review, we present an overview of the advancements made in aptamers used for biosensors and targeted therapy. For the former, we will discuss multiple aptamer-b...