Molecular Design Strategy to Construct the Near-Infrared Fluorescent Probe for Selectively Sensing Human Cytochrome P450 2J2

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成果类型：

期刊论文

作者：

Ning, Jing;Liu, Tao;Dong, Peipei;Wang, Wei;Ge, Guangbo;...

通讯作者：

Feng, Lei;Ma, Xiaochi

作者机构：

[Yu, Zhenlong; Tian, Xiangge; Dong, Peipei; Sun, Chengpeng; Ning, Jing; Wang, Bo; Huo, Xiaokui; Wang, Chao; Feng, Lei; Ma, Xiaochi; Shi, Lei] Dalian Med Univ, Coll Pharm, Natl & Local Joint Engn Res Ctr Drug Dev Neurodeg, Coll Integrat Med, Dalian 116044, Peoples R China.

[Ning, Jing; Liu, Tao; Cui, Jingnan; Feng, Lei] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China.

[Wang, Wei] Hunan Univ Chinese Med, Sch Pharm, Sino Pakistan TCM & Ethnomed Res Ctr 8, TCM & Ethnomed Innovat & Dev Int Lab, Changsha 410208, Hunan, Peoples R China.

[Ge, Guangbo] Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Med Res, Shanghai 201203, Peoples R China.

[James, Tony D.] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England.

通讯机构：

[Feng, L; Ma, XC; Feng, Lei] D

Dalian Med Univ, Coll Pharm, Natl & Local Joint Engn Res Ctr Drug Dev Neurodeg, Coll Integrat Med, Dalian 116044, Peoples R China.

Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China.

语种：

英文

期刊：

Journal of the American Chemical Society

ISSN：

0002-7863

年：

2019

卷：

141

期：

页码：

1126-1134

DOI：

10.1021/jacs.8b12136

基金类别：

The authors thank the National Natural Science Foundation of China (81622047, 81503201, 81473334 and 21572029), the Distinguished Professor of Liaoning Province program and State Key Laboratory of Fine Chemicals (KF1603) for financial support. T.D.J. thanks the Royal Society for a Wolfson Research Merit Award.

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Cytochrome P450 2J2 (CYP2J2), a key enzyme responsible for oxidative metabolism of various xenobiotics and endogenous compounds, participates in a diverse array of physiological and pathological processes in humans. Its biological role in tumorigenesis and cancer diagnosis remains poorly understood, owing to the lack of molecular tools suitable for real-time monitoring CYP2J2 in complex biological systems. Using molecular design principles, we were able to modify the distance between the catalytic unit and metabolic recognition moiety, allowing...

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Molecular Design Strategy to Construct the Near-Infrared Fluorescent Probe for Selectively Sensing Human Cytochrome P450 2J2

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