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Higenamine exerts antidepressant effect by improving the astrocytic gap junctions and inflammatory response.

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成果类型:
期刊论文
作者:
Yao, Jiao;Chen, Cong;Sun, Yang;Lin, Yuting;Tian, Zhifeng;...
通讯作者:
Chen, Naihong;Yang, Yantao;Yang, Songwei
作者机构:
[Ai, Qidi; Lin, Yuting; Yao, Jiao; Liu, Xinya; Tian, Zhifeng; Sun, Yang; Wang, Huiqin; Lin, Meiyu; Yang, Songwei; Yan, Qian; Yang, Yantao; Long, Junpeng] Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China
[Ai, Qidi; Lin, Yuting; Yao, Jiao; Liu, Xinya; Tian, Zhifeng; Sun, Yang; Wang, Huiqin; Lin, Meiyu; Yan, Qian; Long, Junpeng] Key Laboratory of Modern Research of TCM, Education Department of Hunan Province, Changsha 410208, China
[Chen, Cong] School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China
[Gao, Yan] Biomedical Innovation Center, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
[Chen, Naihong] State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China. Electronic address: chennh@imm.ac.cn
通讯机构:
[Chen, Naihong] S
[Yang, Yantao; Yang, Songwei] K
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China. Electronic address:
Key Laboratory of Modern Research of TCM, Education Department of Hunan Province, Changsha 410208, China. Electronic address:
语种:
英文
关键词:
Connexin 43;Depression;Gap junction;Higenamine;Inflammation
期刊:
Journal of Affective Disorders
ISSN:
0165-0327
年:
2024
卷:
348
页码:
107-115
机构署名:
本校为第一且通讯机构
院系归属:
药学院
摘要:
BACKGROUND: Depression is a refractory psychiatric disorder closely associated with dysfunction of the gap junctions (GJs) between astrocytes as well as neuroinflammation. Higenamine (Hig) is a potent cardiotonic ingredient in Fuzi (i.e., Aconitum carmichaeli Debx.) with anti-inflammatory and antioxidant effects, which has a significant protective effect on damaged nerve cells and has great potential for the treatment of neuropsychiatric diseases. METHODS: Rats were stimulated by chronic unpredictable stress (CUS) for 28days while given Hig (5, 10, 20mg/kg) and then analyzed behaviorally by th...

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