With the rapid development of life science and modern biomedicine,humans have had a deep understanding of tumors,and have been actively seeking effective means to treat tumors.Toll-like receptor 4(TLR4) is the first TLR family member identified and reported to regulate inflammatory response.Current studies have shown that TLR4 is involved in mediating many processes including tumor immunity,tumor inflammation,tumor invasion and metastasis,and tumor drug therapy,through myeloid differentiation factor-dependent and independent pathways.This review summarized the recent progress of TLR4 receptor ...