期刊论文

In Vitro and in Vivo Antibacterial Activities of Levofloxacin against Clinic Isolates

中文

医药导报

1004-0781

2007

26

9

983-986

10.3870/j.issn.1004-0781.2007.09.003

本校为第一机构

目的 评价盐酸左氧氟沙星对临床常见致病菌的体内外抗菌活性.方法 采用试管二倍稀释法测定最低抑菌浓度(MIC),并对其影响因素进行测定,同时与时照药左氧氟沙星、氧氟沙星进行对比.结果 盐酸左氧氟沙星对金黄色葡萄球菌(金葡菌)、表皮葡萄球菌、肺炎球菌等革兰阳性菌有较强的抗菌活性,MIC50为0.16～0.62 μg·mL-1;对肠杆菌科细菌如变形杆菌、大肠埃希菌、肺炎克雷白杆菌等革兰阴性菌也有较强的抗菌活性,MIC50为0.31～1.25 μg·mL-1;盐酸左氧氟沙星在酸性条件下抗菌活性降低,随着血清浓度及细菌接种量的提高,盐酸左氧氟沙星的MIC值增大2～4倍;盐酸左氧氟沙星对金葡菌、大肠埃希菌感染小鼠有明显...

Objective To evaluate in vitro and in clinical isolates and compare with levofloxacin and ofloxacin . vivo antibacterial activities of levofloxacin hydrochloride against Methods Minimal inhibitory concentration （MIC） tests were carried out using the broth-dilutions methods . The affecting factors were also determined. Drugs were administered intravenously 1 h after mice were infected intraperitoneally with 1 mL of bacterial suspension . The median effective dose （ ED50 ） was calculated by the probit method. Results Levofloxacin hydrochlorid...