Buyang huanwu decoction combined with BMSCs transplantation promotes recovery after spinal cord injury by rescuing axotomized red nucleus neurons

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成果类型：

期刊论文

作者：

Yang, Ping;Chen, An;Qin, You;Yin, Jian;Cai, Xiong;...

通讯作者：

Li, Liang;Huang, HY

作者机构：

[Yang, Ping; Fan, Yu-jie] Hunan Brain Hosp, Dept Psychiat, 427 Middle Furong Rd, Changsha 410007, Hunan, Peoples R China.

[Cai, Xiong; Li, Liang; Huang, Hui-yong] Hunan Univ Chinese Med, Prov Key Lab TCM Diagnost, 300 Xue Shi Rd, Changsha 410208, Hunan, Peoples R China.

[Yin, Jian; Chen, An] Hunan Univ Chinese Med, Dept Anat, 300 Xue Shi Rd, Changsha 410208, Hunan, Peoples R China.

[Qin, You] Hunan Acad Chinese Med, Inst Chinese Mat Med, 8 Yuehua Rd, Changsha 410013, Hunan, Peoples R China.

[Huang, Hui-yong; Li, Liang] Hunan Univ Chinese Med, Prov Key Lab TCM Diagnost, Sci & Educ Pk, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Huang, HY ; Li, L] H

Hunan Univ Chinese Med, Prov Key Lab TCM Diagnost, Sci & Educ Pk, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

CD71 antigen;cyclic AMP responsive element binding protein binding protein;Hermes antigen;messenger RNA;nerve growth factor;RhoA guanine nucleotide binding protein;buyang huanwu;herbaceous agent;animal cell;animal experiment;Article;bone marrow;bone marrow derived mesenchymal stem cell;bone marrow transplantation;buyang huanwu decoction;Chinese medicine;comparative study;enzyme linked immunosorbent assay;flow cytometry;forelimb;immunohistochemistry;motor performance;nerve cell;nerve function;neuroprotection;Nissl staining;nonhuman;protein expression;quantitative analysis;quantitative real time polymerase chain reaction;rat;real time polymerase chain reaction;red nucleus;rubrospinal tract;spinal cord injury;Western blotting;animal;axotomy;male;mesenchymal stem cell;mesenchymal stem cell transplantation;pathophysiology;physiology;phytotherapy;spinal cord injury;Sprague Dawley rat;Animals;Axotomy;Drugs, Chinese Herbal;Male;Mesenchymal Stem Cell Transplantation;Mesenchymal Stem Cells;Neurons;Phytotherapy;Rats, Sprague-Dawley;Red Nucleus;Spinal Cord Injuries

期刊：

Journal of Ethnopharmacology

ISSN：

0378-8741

年：

2019

卷：

228

页码：

123-131

DOI：

10.1016/j.jep.2018.09.028

基金类别：

This work was supported by grants from the National Natural Science Foundation of China (No. 81302899 , 81373551 and 81603512 ), Natural Science Foundation of Hunan Province (No. 2018JJ2289 ), Key Science and Research Program of Department of Science and Technology of Hunan Province (No. 2012TF-1005 ), China Postdoctoral Science Foundation (No. 2017T100604 and 2016M600632 ). We are grateful for the support by the Institute of Diagnostics of TCM and Department of Anatomy, Hunan University of Chinese Medicine, Changsha, China. This work was supported by grants from the National Natural Science Foundation of China (No. 81302899, 81373551 and 81603512), Natural Science Foundation of Hunan Province (No. 2018JJ2289), Key Science and Research Program of Department of Science and Technology of Hunan Province (No. 2012TF-1005), China Postdoctoral Science Foundation (No. 2017T100604 and 2016M600632). We are grateful for the support by the Institute of Diagnostics of TCM and Department of Anatomy, Hunan University of Chinese Medicine, Changsha, China.

机构署名：

本校为通讯机构

院系归属：

中医学院

中医诊断研究所

摘要：

Ethnopharmacological relevance: Buyang huanwu decoction (BYHWD) is a classic recipe in traditional Chinese medicine (TCM) to supplement Qi and activate blood. It has been used to recover the neural function after the injury of central nervous system for hundreds of years in China. Aim of the study: This study investigated whether Buyang huanwu decoction (BYHWD) combined with bone marrow mesenchymal stem cells (BMSCs) transplantation had synergistic effect on neuroprotection of red nucleus neurons after spinal cord injury (SCI). Materials and me...

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Buyang huanwu decoction combined with BMSCs transplantation promotes recovery after spinal cord injury by rescuing axotomized red nucleus neurons

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