Buyang Huanwu decoction facilitates the repair of red nucleus neurons subsequent to spinal cord injury in rats via autophagy

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Deng, Jianxiong;Zhang, Yihui;Xie, Weiqi;Li, Liang;Li, Qiang

通讯作者：

Li, Q

作者机构：

[Deng, Jianxiong; Li, Qiang; Zhang, Yihui; Li, Q] Second Peoples Hosp Hunan Prov, Spine Surg Dept, 427,Sect 3,Furong Middle Rd, Changsha, Peoples R China.

[Deng, Jianxiong; Xie, Weiqi; Zhang, Yihui] Hunan Univ Tradit Chinese Med, Changsha, Peoples R China.

[Xie, Weiqi] Second Peoples Hosp Hunan Prov, Psychiat Dept, Changsha, Peoples R China.

[Li, Liang] Hunan Univ Chinese Med, Prov Key Lab TCM Diagnost, Changsha, Peoples R China.

通讯机构：

[Li, Q ] S

Second Peoples Hosp Hunan Prov, Spine Surg Dept, 427,Sect 3,Furong Middle Rd, Changsha, Peoples R China.

语种：

英文

关键词：

Spinal cord injury (SCI);Autophagy;Buyang Huanwu Decoction;Rubrospinal tract;Red nucleus

期刊：

JOURNAL OF SPINAL CORD MEDICINE

ISSN：

1079-0268

年：

2025

页码：

1-12

DOI：

10.1080/10790268.2025.2460303

基金类别：

National Natural Science Foundation of China [82374323]; Hunan Provincial Natural Science Foundation [2022JJ30435]; Research Project of Hunan Provincial Health Commission [C202302087602]; Graduate innovation project of Hunan University of Traditional Chinese Medicine [2024CX072]; Hunan Provincial Natural Science Fund project [2024JJ5223]; Fund project of Hunan Provincial Administration of Traditional Chinese Medicine [A2023044]; Hunan University of Traditional Chinese Medicine graduate innovation project [2023CX180, 2024CX153]; Hunan University of Traditional Chinese Medicine undergraduate Research and innovation Fund [2023BKS024]

机构署名：

本校为其他机构

院系归属：

中医学院

中医诊断研究所

摘要：

BACKGROUND: To explore the effects of Buyang Huanwu Decoction (BYHWD) on neurons in the red nucleus of rats with spinal cord injury (SCI) based on autophagy. METHODS: 120 Sprague-Dawley (SD) rats were randomly divided into 6 groups: Control Group, SCI Group, Bafilomycin A1 Group, Rapamycin Group, BYHWD low-dose group (BL Group, 6.25 g/kg), BYHWD high-dose group (BH Group, 25.00 g/kg), with 20 animals in each group. A rat rubrospinal tract (RST) transection model was established and treated for 28 days. The recovery of motor function of rats was observed through inclined plate test and spontane...

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Buyang Huanwu decoction facilitates the repair of red nucleus neurons subsequent to spinal cord injury in rats via autophagy

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