期刊论文

Experimetal Studies on Joint Effect of Gentamycin and Dexamethason in the Treatment of Septic Shock Induced by Live E. Coli in Dogs

中文

中国现代应用药学

1007-7693

1990

1

1-4

10.13748/j.cnki.issn1007-7693.1990.01.001

本校为第一机构

用庆大霉素和地塞米松联合治疗由活大肠杆菌所至的感染性休克合并DIC的犬,可显著提高动物的存活率,改善动脉血压,防止血浆纤维蛋白原的减少,遏制中性粒细胞、血浆超氧化物歧化酶和谷胱甘肽过氧化物聘减少,阻止血浆丙二醛升高,稳定细胞膜和维持血糖水平。

Septic shock in dogs was induced by intravenous injection of live E. coli. Group A receivedgentamycin and dexamethason, group B received saline. The survial rate in 48 hr was statisticallyhigher and the MAP 6 hr after the inlection of live E. Coli was improved for group A. Thechanges of platelet count, fibrinogen, WBC and PMN count, AT-III activity showed that septinshock and DIC were depresed in group A. In contrast with saline group (group B), GS, SOD,GSH-Px were higher, β-GC, MDA were lower in group A. These facts demonstrated that joint ef...