期刊论文

中文

中国医院药学杂志

1001-5213

2012

32

10

763-765

10.13286/j.cnki.chinhosppharmacyj.2012.10.006

国家中医药管理局新药开发专项课题（编号：D2X034B） 广东省科技计划项目（编号：2005833001012） 广州市科技攻关计划引导项目（编号：200523-E5021）

本校为第一机构

目的：评价前列清颗粒的抗炎、镇痛作用。方法：设前列清颗粒高、中、低3个剂量组以及吲哚美辛对照组和空白对照组，采用大鼠角叉菜胶足跖肿胀实验和小鼠二甲苯耳郭肿胀试验，观察前列清颗粒的抗炎作用；采用小鼠热板镇痛试验和扭体镇痛试验，观察前列清颗粒的镇痛作用。结果：与空白对照组比较，前列清颗粒3个剂量组能明显减轻大鼠足跖肿胀率（P〈0．01）；前列清颗粒中、高剂量组对小鼠耳郭肿胀具有显著的抑制作用（P〈0．05，P〈0．01）；3组均能明显延长小鼠痛阈值（P〈0．05，P〈0．01）；显著延长小鼠扭体的潜伏时间，减少扭体次数（P〈0．05，P〈0．01）。结论：前列清颗粒具有一定的抗炎...

OBJECTIVE To evaluate the anti-inflammatory and analgesic effects of Qianlieqing granule （QLQG） in animal models. METHODS The rats were divided into five groups： groups of high, middle and low dose of QLQG, indometacin control group and blank control group. The anti-inflammatory effects were studied by carrageenin-induced paw edema in rats and dimethylbenzene-induced auricle swelling in mice. The analgesic effects were studied by hot-plate test and acetic acid-induced writhing experiment in mice. RESULTS The paw swelling percentage of rats i...