期刊论文

中文

中国现代应用药学

1007-7693

2015

32

3

381-385

10.13748/j.cnki.issn1007-7693.2015.03.030

湖南省高校创新平台开发基金项目（11K048） 湖南省研究生科研创新项目（CX2013B329）

本校为第一机构

降钙素基因相关肽(calcitonin gene-related peptide,CGRP)是目前已知的体内作用最强的内源性舒血管活性肽。近年来CGRP已成为国内外偏头痛治疗领域的研究热点,大量文献显示其在偏头痛三叉神经血管系统(trigeminal vascular system,TGVS)中发挥重要作用,甚至有的研究者认为抑制CGRP的释放和CGRP受体的活性是偏头痛治疗的关键切入点。由此,本文通过综述国内外关于CGRP及偏头痛三叉神经血管系统机制文献,以期能阐明偏头痛发作中CGRP的作用,为基于CGRP的已有治疗药物和新的偏头痛治疗药物提供理论支持。

Calcitonin gene related peptide（Calcitonin gene-related peptide,CGRP） is currently known as the strongest endogenous active peptide of diastolic blood vessels in the body.In recent years,CGRPhas become ahot research topic in the field of treating migraine athome and abroad.A large number of literature shows that the trigeminal vascular system（TGVS） plays an important role in migraine.Even some researchers pointed that inhibiting the release of CGRP and the activity of CGRP receptor is the key point of migraine treatment.In order to clarify ...