期刊论文

中文

中国医院药学杂志

1001-5213

2015

35

14

1295-1297

10.13286/j.cnki.chinhosppharmacyj.2015.14.11

湖南省高校创新平台开发基金项目（11K048） 湖南省研究生科研创新项目（CX2013B329）

本校为其他机构

目的:研究尼莫地平联用小剂量阿司匹林对利血平化低五羟色胺伴局部脑血管痉挛偏头痛模型小鼠的影响。方法:按体质量将50只小鼠采用随机数字表法分成空白对照组(A组),模型空白组(B组),尼莫地平联用小剂量阿司匹林组(C组),尼莫地平单用组(D组),每组12只;采用右肩部位皮下注射利血平(10 mg·kg~(-1)) 14 d复制小鼠偏头痛模型,第14天时每只小鼠经颅穿刺大脑皮层注射自身鼠血凝块2 μl,观察小鼠体质量,采用毛玻璃管法测凝血时间,ELISA法检测血清中5-HT及其代谢产物5-HIAA含量。结果:与模型组比较,尼莫地平联用小剂量阿司匹林能增加利血平化低5-HT伴局部脑血管痉挛偏头痛模型小鼠体质量(P

OBJECTIVE To study the role of Nimodipine combined with low dosage aspirin in the migraine model mice of low5-HT with local cerebral vasospasm induced by reserpine.METHODS 50 mice were randomly divided into 4 groups：blank group,model group,Nimodipine combined with low dosage Aspirin group,Nimodipine group.By giving hypodermic injection of 10 mg·kg^-1 reserpine for 14 days,copied migraine model was established.On the 14 th day after ether anesthesia in mice,puncture cerebral cortex（APo,Lo）to inject blood clots（2μl per mice）was conducted,t...