期刊论文

Zhuanggu Zhitong Capsule Protect Against Postmenopausal Osteoporosis Induced by Ovariectomy Via Estrogen Recepor-Related Receptor in Rats

中文

中国现代应用药学

1007-7693

2016

33

6

690-694

10.13748/j.cnki.issn1007-7693.2016.06.03

国家自然科学基金项目（81273816）；

本校为其他机构

目的通过检测ERRα特异抑制剂XCT790对壮骨止痛胶囊(Zhuanggu Zhitong Capsule,ZGZTC)抗骨质疏松作用的影响,探讨ZGZTC抗骨质疏松作用机理。方法70只8月龄SD大鼠随机分为假手术组、模型组、XCT790组、ZGZTC组、XCT790高剂量+ZGZTC组、XCT790中剂量+ZGZTC组、XCT790低剂量+ZGZTC组,每组10只,切除卵巢后1周,XCT790组每隔3 d皮下注射XCT790橄榄油溶液,非XCT790组皮下注射无菌橄榄油,ZGZTC组每天灌胃给药1次,连续12周,最后一次给药后1 h腹腔注射水合氯醛麻醉,腹主动脉放血处死,取右股骨检测骨密度和骨生物力学,左股骨ELISA检测ERRα蛋白水平,左胫骨RT-PCR检测ERRα mRNA的表达,右胫骨病理切片免疫组...

OBJECTIVE To unveil the mechanism of Zhuanggu Zhitong Capsule (ZGZTC) protecting against postmenopausal osteoporosis induced by ovariectomy with XCT790 blocking estrogen receptor-related receptor. METHODS Seventy 8-month old Sprague Dawley female rats were randomly allocated into sham-operation group, model group, XCT790 group, ZGZTC group, XCT790 high dose + ZGZTC group, XCT790 middle dose + ZGZTC group, XCT790 low dose + ZGZTC group, 10 rats in each group. The rats in sham-operation group were retained ovary with only removing some fat near o...