期刊论文

Effects of Zuogui Jiangtang Jieyu Fang on Synaptic Function Plasticity in Hippocampal Neurons of Diabetes Mellitus with Depression Model Rats

中文

中国现代应用药学

1007-7693

2016

33

5

521-525

10.13748/j.cnki.issn1007-7693.2016.05.001

国家自然科学基金

本校为其他机构

目的针对NR受体亚型及其下游分子CaMKII、SynGAP的表达情况,探索左归降糖解郁方对糖尿病并发抑郁症模型大鼠海马神经元突触功能可塑性的影响。方法复制糖尿病并发抑郁症大鼠模型并随机分为4组:模型组,阳性药组(二甲双胍0.18 g·kg~(-1)+盐酸氟西汀1.8 mg·kg~(-1)),左归降糖解郁方高、低剂量组(32.82,8.20 g·kg~(-1)),以正常大鼠为空白对照组。采用Morris水迷宫检测大鼠的空间学习记忆能力,Western-blotting实验检测大鼠海马NR2A、NR2B、CaMKII、 SynGAP的表达情况。结果与空白对照组比较,模型组大鼠逃避潜伏期延长,空间探索时间减少(P

OBJECTIVE To explore the effects of Zuogui Jiangtang Jieyu Fang on diabetes mellitus plasticity of synaptic function in hippocampal neurons of diabetes mellitus model rats with depression according to the expression of NR receptor subtype and its downstream molecular Ca MKII, Syn GAP. METHODS The diabetes mellitus with depression rat model was established, and the rats were randomly divided into 4 groups： model group, positive drug group（metformin 0.18 g·kg^1＋ fluoxetine hydrochloride 1.8 mg·kg^1）, Zuogui Jiangtang Jieyu Fang high and low...