期刊论文

Optimization Extraction and Inclusion Process of Liqi Huoxue Recipe Volatile Oil Based on Multiple Index Comprehensive Evaluation Method

中文

中国现代应用药学

1007-7693

2019

36

11

1358-1362

10.13748/j.cnki.issn1007-7693.2019.11.009

:湖南省大学生研究性学习和创新性实验计划项目 (4901-0200002006):湖南中医药大学一流学科建设项目

本校为第一机构

目的研究β-环糊精包合理气活血方混合挥发油的最佳工艺。方法采用饱和水溶液法和研磨法对混合挥发油进行包合,通过正交试验设计对包合工艺条件进行优选,通过熵权法确定各指标的权重系数,采用薄层色谱法、红外光谱法对包合物进行验证。结果最佳包合方法是饱和水溶液法,挥发油和β-环糊精的比例为1∶10,转速为50 r·min-1,温度为40℃。结论优选的包合工艺操作简便、工艺稳定、挥发油包合率和包合物得率高。

OBJECTIVE To optimize the the preparation process of the mixed volatile oil of Liqi Huoxue Recipe wrapped with b-cyclodextrin. METHODS Saturated aqueous solution method and grinding method were used to encapsulate the mixed volatile oil. The optimum encapsulation method was selected. The encapsulation conditions were optimized by orthogonal design. The weight coefficients of each index were determined by entropy weight method. Inclusion complexes were verified by TLC and IR. RESULTS The best inclusion method was saturated aqueous solution metho...