期刊论文

Study on the Transport Kinetics Character in Vivo of Double Nicotinate-curcumin Ester Nanoparticles and Nicotinate-curcumin Ester

Liao, D.

中文

中国现代应用药学

1007-7693

2019

36

2

133-137

10.13748/j.cnki.issn1007-7693.2019.02.001

国家自然科学基金项目（81673722） 湖南省教育厅科学研究项目（16A156）

本校为第一且通讯机构

目的提高双烟酸姜黄素酯的生物利用度,考察双烟酸姜黄素酯是否代谢为姜黄素.方法以新西兰家兔为试验对象,采用口服给予双烟酸姜黄素酯纳米粒与双烟酸姜黄素酯原料药后,在不同时间点采血,HPLC测定血中双烟酸姜黄素酯、姜黄素等成分含量,计算体内药物转运动力学参数AUC,比较两者的差别.结果采用统计矩法中的零阶矩法计算AUC,原料药的AUC平均值为(354.835±8.660)µg·L~(-1)·h,而纳米粒的AUC平均值为(883.335±16.37) µg·L~(-1)·h.纳米粒的AUC是原料药AUC的2.486倍.可知纳米粒与原料药相比显著提高了生物利用度;血中未检测到姜黄素.结论双烟酸姜黄素酯制成纳米粒可显著提高双烟酸姜黄素酯的生...

OBJECTIVE To evaluate bioavailability and whether dual nicotinate-curcumin ester is metabolized to curcumin of this nanoparticles in comparison with dual nicotinate-curcumin ester. METHODS New Zealand rabbits were selected as experiment object, blood samples were collected at different intervals after the dual nicotinate-curcumin ester nanoparticles and dual nicotinate-curcumin ester crude drug was given. The content of dual nicotinate-curcumin ester, curcumin in the blood were detected by HPLC. The AUC of transport kinetics character in vivo w...