期刊论文

Effect of Wumoyin Decoction on Regulating Brain-gut Peptide in Functional Dyspepsia Rats with Spleen Deficiency and Qi Stagnation Syndrome

中文

中国现代应用药学

1007-7693

2020

37

7

814-820

10.13748/j.cnki.issn1007-7693.2020.07.008

广东省科技发展专项资金（基础与应用基础研究方向）项目（2016A030307032）；

本校为其他机构

目的研究五磨饮对脾虚气滞证功能性消化不良(functional dyspepsia,FD)大鼠脑肠肽的影响,探讨其作用机制。方法除正常组外,其余大鼠采用"慢性束缚+游泳+饮食不节"复合因素法制备脾虚气滞证FD模型。按体质量随机分为模型组、多潘立酮组、柴芍六君子汤组、五磨饮高剂量组(6.2 g·kg~(-1))、中剂量组(3.1 g·kg~(-1))、低剂量组(1.55 g·kg~(-1))。分组后,除正常组及模型组外,其余大鼠灌胃给药干预14 d。ELISA法检测血浆胃促生长素(Ghrelin)、胃动素(motilin,MTL)、胃泌素(gastrin,GAS)、胆囊收缩素(cholecystokinin,CCK)、血管活性肠肽(vasoactive intestinal peptide,VIP)、降钙素基因相关肽(cal...

OBJECTIVE To study the effect of Wumoyin decoction on regulating functional dyspepsia rats with spleen deficiency and qi stagnation syndrome,explore its mechanism of action.METHODS Except the normal group,the other rats were modeled by "chronic restraint+swimming+irregular eating" compound factor method.The rats were randomly divided into model group,domperidone group,Chaishao Liujunzi decoction group,Wumoyin decoction high dose group(6.2 g·kg~(-1)),middle dose group(3.1 g·kg~(-1)) and low dose group(1.55 g·kg~(-1)).Besides the normal group ...