期刊论文

Research on Formulation Optimization and Hygroscopicity of New Five-juice Decoction Granules

中文

中国现代应用药学

1007-7693

2021

38

02

173-178

10.13748/j.cnki.issn1007-7693.2021.02.008

湖南省教育厅科学研究基金（18B237,19K070）；

本校为第一机构

目的优选新五汁饮颗粒剂制剂处方配比,考察新五汁饮颗粒剂吸湿性,为将其开发成药膳普通食品提供依据。方法以外观、澄明度、溶化性、色泽、口感等为评价指标,采用等级一致性检验法优选新五汁饮颗粒剂制剂处方中稀释剂、润湿剂、矫味剂等辅料及其用量;以颗粒收率、休止角（流动性）为评价指标,验证制剂处方优化结果,通过吸湿性试验确定临界相对湿度等参数。结果新五汁饮颗粒剂最优制剂处方:新五汁饮干浸膏粉1.0份,乳糖1.0份,赤鲜醇1.0份;95%乙醇制软材,湿法制粒,50℃减压干燥4 h;在不同湿度下吸湿速度动力学方程皆满足幂函数数学模型,吸湿百分率为5%时对应时间（Y）与环境相对湿度（X）最接近的数...

OBJECTIVE To optimize the formulation and investigate the hygroscopicity of New Five-juice Decotion granules, so as to provide a basis for developing new five-juice decoction granules into herbal cuisine plain food. METHODS Appearance, clarity, melting, color, mouthfeel, etc were used as evaluation indexes. The amount or ratio of excipients in formulation of New Five-juice Decoction granules like the diluent, wetting agent, flavoring agent, etc were optimized by grade-consistency-test-method. Particle yield and angle of repose(fluidity) were us...