期刊论文

Li, X.

中文

中国现代应用药学

1007-7693

2022

39

18

2367-2376

10.13748/j.cnki.issn1007-7693.2022.18.011

国家自然科学基金项目（82060839）； 江西省卫生健康委科技计划（20204305）； 江西省中医药科研计划（2019A395）；

本校为第一且通讯机构

目的 结合meta分析与网络药理学研究策略,评价肾复康胶囊(Shenfukangcapsule,SKC)治疗慢性肾小球肾炎(chronicglomerulonephritis,CGN)的临床疗效,并初步探索其作用机制。方法 全面检索SKC治疗CGN随机对照试验(randomized controlled trials,RCTs)研究的中英文文献,基于纳、排标准,确定定量文献,采用Review Manager对纳入数据meta分析。基于网络药理学方法,筛选SKC的化学成分及其作用靶点、疾病靶点、共有靶点等相关信息,随后基于生物信息学技术,进行关键通路的相关注释,探讨SKC干预CGN潜在机制。结果 共纳入11项RCTs,合计938例受试者。Meta分析显示,在有效率、淋巴细胞亚群(CD4、CD4/CD8升高,C...

OBJECTIVE To investigate clinical efficacy evaluation and potential mechanism of Shenfukang capsule(SKC) in treatment to chronic glomerulonephritis(CGN) based on integration meta analysis and network pharmacology research strategy. METHODS The Chinese and English literature of the randomized controlled trials(RCTs) about SKC in treatment on CGN were comprehensively searched. The quantitative literature was determined based on the criteria of inclusion and exclusion. The meta analysis of the included data was carried out by the Review Manager. T...