期刊论文

中文

广东医学

1001-9448

2023

44

12

1554-1559

10.13820/j.cnki.gdyx.20232407

202232102017:湖南省卫生健康委科研项目

本校为第一机构

目的 探讨口腔上皮细胞具核梭杆菌预测口腔鳞状细胞癌(OSCC)患者的预后价值.方法 收集湖南中医药大学第二附属医院2018年12月至2022年4月151例OSCC的患者,实时定量荧光定量PCR对具核梭杆菌(Fn)基因序列进行定量.LPS和CD163免疫染色剂检测革兰氏阴性菌和巨噬细胞.评估肿瘤内Fn与两个独立的OSCC患者队列中的临床病理特征,复发和总生存期(OS)之间的关系,并探索与免疫相关基因的相互作用.结果 Fn阳性与年龄较大、饮酒和饮酒加吸烟摄入较少以及淋巴结浸润频率较低有关;与Fn阴性肿瘤相比,转移性复发较少,OS、无复发和无转移生存期明显延长,免疫相关基因和免疫组织化学分析表明,Fn阳性与M2巨噬细胞呈负...

Objective To investigate the prognostic value of Fusobacterium nucleatum in oral epithelial cells in patients with oral squamous cell carcinoma(OSCC).Methods A total of 151 patients with OSCC treated at the Second Affiliated Hospital of Hunan University of Chinese Medicine from December 2018 to April 2022 were included.Real-time quantitative fluorescence PCR was used to quantify the Fusobacterium nucleatum(Fn)gene sequences.Gram-negative bacteria and macrophages were detected using LPS and CD 163 immunostaining.The correlation between tumor-ass...