Identification of tryptophan metabolism-related genes in immunity and immunotherapy in Alzheimer\'s disease - 成果

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Identification of tryptophan metabolism-related genes in immunity and immunotherapy in Alzheimer's disease

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Song, Zhenyan;Wu, Zixuan;Luo, Rongsiqing;He, Chunxiang;Li, Ze;...

通讯作者：

Cheng, SW

作者机构：

[He, Chunxiang; Li, Ze; Song, Zhenyan; Cheng, Shaowu; He, Jiawei; Cheng, SW; Luo, Rongsiqing; Yang, Miao; Yu, Wenjing; Deng, Sisi] Hunan Univ Chinese Med, Sch Integrated Chinese & Western Med, Changsha 410208, Hunan, Peoples R China.

[He, Chunxiang; Li, Ze; Wu, Zixuan; Song, Zhenyan; Cheng, Shaowu; He, Jiawei; Cheng, SW; Luo, Rongsiqing; Yang, Miao; Yu, Wenjing; Deng, Sisi] Hunan Univ Chinese Med, Key Lab Hunan Prov Integrated Tradit Chinese & Wes, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Cheng, SW ] H

Hunan Univ Chinese Med, Sch Integrated Chinese & Western Med, Changsha 410208, Hunan, Peoples R China.

Hunan Univ Chinese Med, Key Lab Hunan Prov Integrated Tradit Chinese & Wes, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Alzheimer’s disease;DEGs;WGCNA;bioinformatics;tryptophan metabolism-related genes

期刊：

AGING-US

ISSN：

1945-4589

年：

2023

卷：

期：

页码：

13077-13099

DOI：

10.18632/aging.205220

基金类别：

National Natural Science Foundation of China [82074046, 82004184]; Science and Technology Innovation Program of Hunan Province [2023RC3166]; Natural Science Foundation of Hunan Province for Excellent Youth Project [2023JJ20033]; Hunan Provincial "Shennong talent" Project

机构署名：

本校为第一机构

院系归属：

中西医结合学院

摘要：

Recent studies have highlighted the significant involvement of tryptophan metabolism in the pathogenesis of Alzheimer's disease (AD). However, a comprehensive investigation of the precise role of tryptophan metabolism in the context of AD is still lacking. This study employed a bioinformatics approach to identify and validate potential tryptophan metabolism-related genes (TrpMgs) associated with AD. The discovery of TrpMgs was facilitated through the intersection of the Weighted Gene Co-expression Network Analysis (WGCNA) test and 17 known tryptophan metabolism pathways. Subsequently, the puta...

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Identification of tryptophan metabolism-related genes in immunity and immunotherapy in Alzheimer's disease

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