Da-Bu-Yin-Wan Improves the Ameliorative Effect of DJ-1 on Mitochondrial Dysfunction Through Augmenting the Akt Phosphorylation in a Cellular Model of Parkinson\'s Disease - 成果

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Da-Bu-Yin-Wan Improves the Ameliorative Effect of DJ-1 on Mitochondrial Dysfunction Through Augmenting the Akt Phosphorylation in a Cellular Model of Parkinson's Disease

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成果类型：

期刊论文

作者：

Zhang, Yi*;Gong, Xiao-Gang;Sun, Hong-Mei*;Guo, Zhen-Yu;Hu, Jing-Hong;...

通讯作者：

Zhang, Yi;Sun, Hong-Mei

作者机构：

[Wang, Yuan-Yuan; Feng, Wan-Di; Zhang, Y; Sun, Hong-Mei; Gong, Xiao-Gang; Zhang, Yi; Guo, Zhen-Yu] Beijing Univ Chinese Med, Sch Tradit Chinese Med, Dept Anat, Beijing, Peoples R China.

[Gong, Xiao-Gang] Beijing Union Univ, Coll Special Educ, Beijing, Peoples R China.

[Hu, Jing-Hong] Beijing Univ Chinese Med, Sch Tradit Chinese Med, Ctr Sci Res, Beijing, Peoples R China.

[Li, Lin] Capital Med Univ, Minist Educ, Key Lab Neurodegenerat Dis, Beijing, Peoples R China.

[Li, Ping] China Japan Friendship Hosp, Inst Clin Med Sci, Beijing Key Lab Immune Mediated Inflammatory Dis, Beijing, Peoples R China.

通讯机构：

[Zhang, Y; Sun, HM] B

Beijing Univ Chinese Med, Sch Tradit Chinese Med, Dept Anat, Beijing, Peoples R China.

语种：

英文

关键词：

Akt;DJ-1;Da-Bu-Yin-Wan;Parkinson's disease;mitochondrial function

期刊：

Frontiers in Pharmacology

ISSN：

1663-9812

年：

2018

卷：

期：

OCT

页码：

1206

DOI：

10.3389/fphar.2018.01206

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81473376, 81573773, 81774110]; Beijing University of Chinese Medicine [81202939]; Open Program of Key Laboratory of Neurodegenerative Diseases of Ministry of Education (Capital Medical University) [2016SJBX03]

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Da-Bu-Yin-Wan (DBYW) is recorded originally in China over six centuries ago, and it is used to treat Parkinson's disease (PD) clinically in recent decades. DJ-1 is a homodimeric protein linked to early-onset PD, and found in the mitochondria. In addition, DJ-1 could protect the cells by regulating gene transcription and modulating the Akt signal pathways. Therefore, in this research, we aimed to investigate the ameliorative effect of DBYW on mitochondria in the view of the DJ-1 and Akt signaling. Rat adrenal pheochromocytoma cell line PC-12 was...

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Da-Bu-Yin-Wan Improves the Ameliorative Effect of DJ-1 on Mitochondrial Dysfunction Through Augmenting the Akt Phosphorylation in a Cellular Model of Parkinson's Disease

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