Kadsura heteroclita stem ethanol extract protects against carbon tetrachloride-induced liver injury in mice via suppression of oxidative stress, inflammation, and apoptosis

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成果类型：

期刊论文

作者：

Yu, Huang-he;Qiu, Yi-xing;Li, Bin;Peng, Cai-yun;Zeng, Rong*;...

通讯作者：

Zeng, Rong;Wang, W

作者机构：

Hunan Univ Chinese Med, TCM & Ethnomed Innovat & Dev Int Lab, Sch Pharm, Changsha 410208, Hunan, Peoples R China.

Hunan Univ Chinese Med, Innovat Mat Med Res Inst, Sch Pharm, Changsha 410208, Hunan, Peoples R China.

[Wang, Wei; Zeng, Rong] Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Peoples R China.

通讯机构：

[Wang, W ; Zeng, R] H

Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Peoples R China.

语种：

英文

关键词：

alanine aminotransferase;aspartate aminotransferase;bifendate;caspase 3;caspase 8;glutathione peroxidase;glutathione peroxidase 2;interleukin 10;interleukin 6;Kadsura heteroclita extract;liver protective agent;malonaldehyde;myeloperoxidase;plant extract;protein Bax;protein bcl 2;superoxide dismutase;tumor necrosis factor;unclassified drug;alcohol;antiinflammatory agent;antioxidant;apoptosis regulatory protein;autacoid;biological marker;carbon tetrachloride;solvent;abdominal cavity;acute toxicity;alanine aminotransferase blood level;animal cell;animal experiment;animal model;animal tissue;antiapoptotic activity;antiinflammatory activity;antioxidant activity;apoptosis;Article;aspartate aminotransferase blood level;carbon tetrachloride-induced liver injury;cell death;cell infiltration;chemoluminescence;controlled study;down regulation;drug mechanism;drug megadose;enzyme activity;female;histopathology;inflammation;inflammatory cell;Kadsura;Kadsura heteroclita;liver cell;liver fibrosis;liver protection;liver tissue;low drug dose;male;maximum tolerated dose;mouse;nonhuman;oxidative stress;protein expression;spleen;thymus;upregulation;Western blotting;animal;apoptosis;blood;chemistry;disease model;drug effect;Institute for Cancer Research mouse;isolation and purification;liver;metabolism;necrosis;oxidative stress;pathology;plant stem;signal transduction;toxic hepatitis;Animals;Anti-Inflammatory Agents;Antioxidants;Apoptosis;Apoptosis Regulatory Proteins;Biomarkers;Carbon Tetrachloride;Chemical and Drug Induced Liver Injury;Disease Models, Animal;Ethanol;Female;Hepatocytes;Inflammation Mediators;Kadsura;Liver;Male;Mice, Inbred ICR;Necrosis;Oxidative Stress;Plant Stems;Signal Transduction;Solvents

期刊：

Journal of Ethnopharmacology

ISSN：

0378-8741

年：

2021

卷：

267

页码：

113496

DOI：

10.1016/j.jep.2020.113496

基金类别：

This work was partially supported by the Natural Science Foundation of China [Grant numbers 81374062 , 81673579 , 81874369 and 81703819 ], Ministry of Science and Technology [Grant numbers 2018YFC1707902 and 2018FY100703 ], Key projects of Hunan Provincial Education Department [Grant numbers 17A157 ], Hunan Provincial Science and Technology Department [Grant numbers 2018WK2081 and 2018SK2110 ], Hunan Provincial Innovation Foundation for Postgraduate [Grant numbers CX2018B476 ].

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Ethnopharmacological relevance: Kadsura heteroclita stem (KHS) is a well-known hepatoprotective Tujia ethnomedicine (folk named Xuetong), has long been used for the prevention and treatment of hepatitis and liver diseases. Aim of the study: To explore the protective effects of KHS against carbon tetrachloride (CCl4)-induced liver injury and the underlying mechanism, particularly antioxidative, anti-inflammatory, and anti-apoptotic potentials. Materials and methods: The acute toxicity of KHS was measured by the method of maximum tolerated dose (...

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Kadsura heteroclita stem ethanol extract protects against carbon tetrachloride-induced liver injury in mice via suppression of oxidative stress, inflammation, and apoptosis

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