Astragaloside VI Promotes Neural Stem Cell Proliferation and Enhances Neurological Function Recovery in Transient Cerebral Ischemic Injuryvia Activating EGFR/MAPK Signaling Cascades

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成果类型：

期刊论文

作者：

Chen, Xi;Wu, Hao;Chen, Hansen;Wang, Qi;Xie, Xue-jiao;...

通讯作者：

Shen, Jiangang

作者机构：

[Chen, Xi; Shen, Jiangang] Peoples Hosp Bao An, Dept Core Facil, Shenzhen, Peoples R China.

[Chen, Xi] Southern Med Univ, Affiliated Bao An Hosp, Peoples Hosp Shenzhen 8, Shenzhen 518000, Peoples R China.

[Chen, Xi; Chen, Hansen; Shen, Jiangang; Wu, Hao] Univ Hong Kong, Sch Chinese Med, Li Ka Shing Fac Med, Pokfulam, 10 Sassoon Rd, Hong Kong, Peoples R China.

[Shen, Jiangang; Wang, Qi] Guangzhou Univ Chinese Med, Inst Clin Pharmacol, Guangzhou, Guangdong, Peoples R China.

[Xie, Xue-jiao] Hunan Univ Chinese Med, Sch Tradit Chinese Med, Changsha, Hunan, Peoples R China.

通讯机构：

[Shen, Jiangang] P

[Shen, Jiangang] U

[Shen, Jiangang] G

Peoples Hosp Bao An, Dept Core Facil, Shenzhen, Peoples R China.

Univ Hong Kong, Sch Chinese Med, Li Ka Shing Fac Med, Pokfulam, 10 Sassoon Rd, Hong Kong, Peoples R China.

语种：

英文

关键词：

Astragaloside VI;Epidermal growth factor;Neural stem cell;Proliferation;Transient cerebral ischemia

期刊：

Molecular Neurobiology

ISSN：

0893-7648

年：

2019

卷：

期：

页码：

3053-3067

DOI：

10.1007/s12035-018-1294-3

基金类别：

Shenzhen Science and Technology Innovation Commission [JCYJ20150402152005623]; State Key Project of National Natural Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81630101, SIRI/04/09/2014/2]; National Natural Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81703741]

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本校为其他机构

摘要：

Radix Astragali (AR) is a commonly used medicinal herb for post-stroke disability in Traditional Chinese Medicine but its active compounds for promoting neurogenic effects are largely unknown. In the present study, we tested the hypothesis that Astragaloside VI could be a promising active compound from AR for adult neurogenesis and brain repair via targeting epidermal growth factor (EGF)-mediated MAPK signaling pathway in post-stroke treatment. By using cultured neural stem cells (NSCs) and experimental stroke rat model, we investigated the effects of Astragaloside VI on inducing NSCs prolifer...

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Astragaloside VI Promotes Neural Stem Cell Proliferation and Enhances Neurological Function Recovery in Transient Cerebral Ischemic Injuryvia Activating EGFR/MAPK Signaling Cascades

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