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Comparative Proteomic Analysis of the Effect of the Four-Herb Chinese Medicine ANBP on Promoting Mouse Skin Wound Healing

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成果类型:
期刊论文
作者:
Chen, Li;Hou, Qian;Zhou, Zhong-Zhi;Li, Mei-Rong;Zhong, Ling-Zhi;...
通讯作者:
He, Wen-Jun;Fu, XB
作者机构:
[Zhong, Ling-Zhi; He, Wen-Jun; Fu, XB; Cheng, Zhong-Yi; Fu, Xiao-Bing; Chen, Li; Zhu, Zi-Ying; Li, Mei-Rong; Deng, Xiang-Dong; Hou, Qian] Chinese Peoples Liberat Army Gen Hosp, Inst Basic Med, 28 Fuxing Rd, Beijing 100853, Peoples R China.
[Chen, Li] Hunan Univ Chinese Med, Changsha, Hunan, Peoples R China.
[Zhou, Zhong-Zhi; Xiang, Cong-Lian] Hunan Univ Chinese Med, Affiliated Hosp 1, Changsha, Hunan, Peoples R China.
[Cheng, Zhong-Yi; Zhu, Jun] Jingjie PTM Biolab Hangzhou Co Ltd, Hangzhou, Zhejiang, Peoples R China.
[He, Wen-Jun; Fu, XB; Fu, Xiao-Bing] Chinese Peoples Liberat Army Gen Hosp, Affiliated Hosp 1, 51 Fucheng Rd, Beijing 100048, Peoples R China.
通讯机构:
[He, WJ; Fu, XB ] C
Chinese Peoples Liberat Army Gen Hosp, Inst Basic Med, 28 Fuxing Rd, Beijing 100853, Peoples R China.
Chinese Peoples Liberat Army Gen Hosp, Affiliated Hosp 1, 51 Fucheng Rd, Beijing 100048, Peoples R China.
语种:
英文
关键词:
ANBP;Chinese drug;unclassified drug;wound healing promoting agent;herbaceous agent;Agrimonia pilosa;animal experiment;animal model;animal tissue;Article;Boswellia sacra;Chinese medicine;controlled study;down regulation;extracellular matrix;gene ontology;granulation tissue;iTRAQ labeling;liquid chromatography-mass spectrometry;male;medicinal plant;mouse;Nelumbo nucifera;nonhuman;Pollen typhae;priority journal;protein analysis;protein expression;proteomics;punch biopsy;quantitative analysis;skin injury;thickness;upregulation;wound closure;wound healing;animal;C57BL mouse;comparative study;disease model;drug effect;genetics;immunohistochemistry;injury;needle biopsy;pathology;randomization;reference value;sensitivity and specificity;skin;wound healing;Animals;Biopsy, Needle;Disease Models, Animal;Drugs, Chinese Herbal;Immunohistochemistry;Male;Mice;Mice, Inbred C57BL;Proteomics;Random Allocation;Reference Values;Sensitivity and Specificity;Skin;Wound Healing;Wounds and Injuries
期刊:
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
ISSN:
1534-7346
年:
2017
卷:
16
期:
3
页码:
154-162
基金类别:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported in part by the National Natural Science Foundation of China (81421064, 81230041, 81501669, and 31100705), the China Postdoctoral Science Foundation (2013M542517), Special Financial grant from the China Postdoctoral Science Foundation (2015T81099), and the Natural Science Foundation of Hunan Province (2016JJ3100).
机构署名:
本校为其他机构
院系归属:
第一中医临床学院
摘要:
Traditional Chinese medicine has great potential to improve wound healing. ANBP, the mixture of 4 Chinese herbs—Agrimoniapilosa, Nelumbonucifera, Boswelliacarteri, and Pollen typhae—is effective in trauma treatment while its mechanism is still elusive. In this study, quantitative proteomics and bioinformatics analyses were performed to decipher the possible roles of ANBP in accelerated wound healing of mouse skin. Among all 3171 identified proteins, 90, 71, 80, and 140 proteins were found to be differently expressed in 6 hours, 3 days, 7 days...

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