Effects of Siniruangan Recipe on Proliferation, Apoptosis and Activation of Human Hepatic Stellate Cell Line LX-2

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成果类型：

期刊论文

作者：

Liu, Jinming;Zhao, Guorong;Ai, Bichen;He, Yirong;Mei, Ming;...

通讯作者：

Zhao, GR

作者机构：

[Zou, Junju; Yin, Zhouan; Liu, Jinming; Mei, Ming] Hunan Univ Chinese Med, Postgrad Sch, Changsha, Hunan, Peoples R China.

[Zhao, Guorong; Xiao, Biyue; He, Yirong; Ai, Bichen; Zhao, GR] Hunan Univ Chinese Med, Coll Tradit Chinese Med, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

[Liu, Jinming] Southern Univ Sci & Technol Hosp, Dept Internal Med, Shenzhen, Guangdong, Peoples R China.

通讯机构：

[Zhao, GR ] H

Hunan Univ Chinese Med, Coll Tradit Chinese Med, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

alpha smooth muscle actin;beta catenin;caspase 3;herbaceous agent;protein Bax;protein bcl 2;siniruangan;tissue inhibitor of metalloproteinase 1;transforming growth factor beta1;unclassified drug;TGFB1 protein, human;TIMP1 protein, human;tissue inhibitor of metalloproteinase 1;transforming growth factor beta1;apoptosis;Article;cell activation;cell culture;cell proliferation;controlled study;cytotoxicity;drug effect;drug mechanism;extracellular matrix;hepatic stellate cell;human;human cell;immunofluorescence;liver fibrosis;priority journal;protein cleavage;protein degradation;protein expression;signal transduction;staining;Western blotting;apoptosis;cell line;cell proliferation;cell survival;drug effect;hepatic stellate cell;liver cirrhosis;metabolism;Apoptosis;Cell Line;Cell Proliferation;Cell Survival;Hepatic Stellate Cells;Humans;Liver Cirrhosis;Tissue Inhibitor of Metalloproteinase-1;Transforming Growth Factor beta1

期刊：

PHARMACOLOGY

ISSN：

0031-7012

年：

2019

卷：

104

期：

5-6

页码：

342-351

DOI：

10.1159/000500800

基金类别：

The study was supported by [1] the research funding of the International Cooperative Science and Technology Project of the Science and Technology Department and Finance Department of Hunan Province (2015WK3019) [2] the key clinical and fundamental disciplines of traditional Chinese medicine in Hunan University of Chinese Medicine.

机构署名：

本校为其他机构

院系归属：

中医学院

研究生院

摘要：

Background: Experimental and clinical evidence suggests that liver fibrosis is potentially reversible. Hepatic stellate cells (HSCs) play a key role in the development of hepatic fibrosis. Previous clinical applications and researches showed that Siniruangan recipe (SNRG) reversed liver fibrosis and even liver cirrhosis. This experimental study aimed to elucidate the effects of SNRG on the proliferation, apoptosis and activation of HSCs. Methods: The human HSCs line LX-2 was cultured with normal culture medium and multi-dose SNRG water decoctio...

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Effects of Siniruangan Recipe on Proliferation, Apoptosis and Activation of Human Hepatic Stellate Cell Line LX-2

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