Delivery of BR2-SOX17 fusion protein can inhibit cell survival, proliferation, and invasion in gastric cancer cells through regulating Klotho gene expression
Department of Education Key Project of Hunan Province [15A024]; Postdoctoral Science Foundation of ChinaChina Postdoctoral Science Foundation [2016M602416]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81704089]; Postdoctoral Science Fund Special Grant of China [2017T100603]; Natural Science Foundation of Huan Provence [2018JJ3400]; Changsha City Outstanding Innovation Youth Program Changsha city [kq1707012]
机构署名：
本校为其他机构
院系归属：
第二中医临床医学院
摘要：
The prognosis of advanced gastric cancer is poor and understanding the biology and subsequent development of new targeting therapy is still an urgent need. This study was conducted to explore the effect of BR2 (a 17-amino acid peptide)-SOX17 (Human sex determining region Y (SRY)-related high-mobility group (HMG) box protein family member 17) fusion protein on Klotho gene expression in gastric cancer cells. The regulatory effects of SOX17 on Klotho gene in gastric cancer cells were tested using dual-luciferase reporter assay and chromatin immunoprecipitation (ChIP) assay. The therapeutic effect...
