期刊论文

Yang, Ping-Chang

英文

中国免疫学杂志：英文版

1672-7681

2013

10

1

78-83

10.1038/cmi.2012.32

Canadian Institute of Health Research (CIHR)Canadian Institutes of Health Research (CIHR) [191063, 220058]; Natural Sciences, Engineering Research Council of Canada (NSERC)Natural Sciences and Engineering Research Council of Canada (NSERC) [371268]; CIHRCanadian Institutes of Health Research (CIHR) [177843]

本校为其他机构

T helper 2 (Th2) polarization is a major pathological feature in allergic diseases; its etiology is not fully understood. This study aims to elucidate the adjuvant effect of the microbial product-derived small peptides in the initiation of antigen-specific Th2 polarization. In this study, a clinical survey of patients with chronic rhinosinusitis (CRS) and food allergy (FA) was carried out. The Staphylococcal enterotoxin B (SEB)-derived small peptides (Ssps) were examined in the human stool extracts. The formation of Ssp/antigen adducts was test...

T 助手 2 (Th2 ) 极化是在过敏疾病的一个主要病理学的特征；它的病原学充分没被理解。这研究试图阐明在抗原特定的 Th2 的开始的微生物引起的导出产品的小肽的辅助效果极化。在这研究，有长期的 rhinosinusitis (CRS ) 和食物过敏症(FA ) 的病人的临床的调查被执行。Staphylococcal enterotoxin B (SEB ) 导出小肽(Ssps ) 在人的凳子摘录被检验。Ssp/antigen 的形成使内收在蛋白质蛋白质联合试金被测试。骨头导出髓的树枝状的房间(BMDC ) 被采用测试 Ssp/ovalbumin (卵) 的角色在树枝状的房间(DC ) 使内收成熟。一个老鼠模型被开发测试 Ssp/OVA 的角色在肠在 Th2 极化的开始使内收。结果显示出...