As a new type of teaching classroom model,the construction and popularization of online first-class courses not only make teachers' teaching and students' learning diversified,and also make the teacher's teaching and research level,student's study interest and ability to the effective promotion."Basic Immunology and Pathogenic Biology",the first national first-class on-line course,has been run for six semesters with 40 395 students in 84 elective schools.This paper summarizes the construction and popularization of the course from six aspects:the construction background and target,overall frame...