This paper systematically described the National Chinese Medicine Master Sun Guangrong's discussion about the six difficulties in clinical traditional Chinese medicine: (1) the index for diagnosis was difficult to objectify, detailed and subtilized; (2) the clinical pathway and treatment plan were difficult to normalized and standardized; (3) the prescription of treat-ment was difficult to format and the dose was difficult to subtilize; (4) the clinical medication is difficult to optimizate; (5) the clinical evaluation was difficult to objectify and subtilized; (6) internationalization of trad...