期刊论文

中文

中国药师

1008-049X

2013

16

8

1156-1159

10.3969/j.issn.1008-049X.2013.08.023

湖南中医药管理局科研计划项目（编号:201164）；

本校为第一机构

目的:研究补中益气丸中黄芪甲苷的转移率,探讨氨试液对补中益气丸中黄芪甲苷转移率的影响.方法:采用HPLC-ELSD法测定补中益气丸中黄芪甲苷的转移率,UPLC-MS液质联用法考察碱性环境(氨试液)下对黄芪甲苷转移率的影响.结果:现行标准下测定补中益气丸中黄芪甲苷转移率高达400％;氨试液作用下,黄芪药材中黄芪皂苷Ⅰ,Ⅱ转化为黄芪甲苷,黄芪皂苷Ⅲ相对稳定.结论:黄芪甲苷转移率存在异常偏高,黄芪药材及含黄芪的制剂以黄芪甲苷作为定量的指标存在着一定的不合理性,其他皂苷类成分可以转化为黄芪甲苷.

Objective：To study the transfer rate of astragaloside in Buzhong Yiqi pills and explore the effects of ammonia solution on the transfer rate.Method：The transfer rate of astragaloside in Buzhong Yiqi pills was determined by HPLC-ELSD,and the change of the astragaloside transfer rate in the alkaline environment（ammonia solution） was studied by UPLC-MS.Result：In the current standard,the transfer rate of astragaloside in Buzhong Yiqi pills was up to 400%,while under the effect of ammonia solution,astragalus saponinⅠandⅡwere transferred to as...