期刊论文

中文

中国药师

1008-049X

2013

16

7

972-974

10.3969/j.issn.1008-049X.2013.07.014

湖南省卫生厅基金项目（编号:201166）；

本校为第一机构

目的：优选乳核分散片的处方和制备工艺参数。方法：以崩解时限和片剂外观作为考察指标,采用均匀设计法优选乳核分散片的处方和制备工艺参数。结果：最佳乳核分散片处方为：38%浸膏粉、46%微晶纤维素（MCC）、8%低取代羟丙基纤维素（L-HPC）、4%羧甲基淀粉钠（CMS-Na）、2%交联聚乙烯吡咯烷酮（PVPP）、2%微粉硅胶;优选的分散片处方崩解时间小于3 mim,分散均匀。结论：优选处方合理,工艺可行,所制备的乳核分散片质量符合相关要求。

To optimize the formula and preparation technology of Ruhe dispersible tablets.Method：The disintegration time and the appearance were observed to screen the optimal preparation technology of Ruhe dispersible tablets by uniform experiment. Result：The optimized formula of Ruhe dispersible tablets was as follows;38%extract powder,47%MCC,8%L-HPC,4%CMSNa, 2%PVPP and 2%aerosil.The optimized dispersible tablets could disintegrate uniformly in 3 minutes,showing promising distribution homogeneity.Conclusion：The optimized formula is reasonable,and the...