期刊论文

Preparation and Determination of Runfu Zhiyang Gels by Orthogonal Test

中文

中国药师

1008-049X

2013

16

4

567-570

10.3969/j.issn.1008-049X.2013.04.033

长沙市科技局基金项目（编号:K1106002-31）；

本校为第一机构

目的：优选润肤止痒凝胶成型工艺条件。方法：以光泽度、涂展性、均匀度及离心性为评价指标,采用正交试验法,对成型工艺中的羧甲基纤维素钠的用量、pH、甘油用量等因素进行优化,并采用高效液相色谱法测定羟基红花黄色素A、苦参碱的含量。结果：优化处方为羧甲基纤维素钠1.0 g、甘油2.0 ml、pH 6.5左右。所得凝胶剂质量稳定,为均一半透明黏稠状凝胶。结论：该脂质体凝胶工艺可行,具有开发价值。

Objective： To optimize the conditions in the preparation process of Runfu Zhiyang gels. Method： The preparation process of the liposomal gels were optimized by orthogonal design with the glossiness, spreading ability, uniformity and centrifugal stabil-ity as the evaluation indices, and the amount of CMC-Na and glycerine and pH value as the influencing factors. The contents of hydroxy safflower yellow A and matrine were determined by HPLC. Result： The optimized prescription was composed of 1.0g CMCNa, 2.0ml glycerine and pH was about 6.5. The...